Expressive

rs10000290 - BST1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Genetic risk loci for Parkinson's disease and dementia in a large-scale population-based Taiwanese cohort (TPMI) - Unknown journal (n.d.) · Unknown authors · PubMed 41810385

    ABSTRACT: Summary Background The genetic architecture of Parkinson's disease (PD) and progression to PD dementia (PDD) remains incompletely characterized in Asians. Here, we investigated genetic risk factors for PD and PDD in Taiwanese individuals from the Taiwan Precision Medicine Initiative (TPMI), the largest non-European cohort integrating genetic and electronic medical record data. Methods We conducted a two-stage population-based case-control genome-wide association study (GWAS) with a 1:10 case-to-control ratio. Results were meta-analyzed with an independent Asian GWAS. We further constructed a polygenic risk score (PRS) to distinguish PD cases from controls. PDD risk was assessed using logistic regression and Cox models, with replication in an independent cohort that underwent wh

  • Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations - Unknown journal (n.d.) · Unknown authors · PubMed 36168886

    ABSTRACT: Abstract Polygenic scores (PGS) can identify individuals at risk of adverse health events and guide genetics-based personalized medicine. However, it is not clear how well PGS translate between different populations, limiting their application to well-studied ethnicities. Proteins are intermediate traits linking genetic predisposition and environmental factors to disease, with numerous blood circulating protein levels representing functional readouts of disease-related processes. We hypothesized that studying the genetic architecture of a comprehensive set of blood-circulating proteins between a European and an Arab population could shed fresh light on the translatability of PGS to understudied populations. We therefore conducted a genome-wide association study with whole-genome

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.