ZFPM1, variants, traits, and what the research shows

ZFPM1 - what this gene does

Variants catalogued at the ZFPM1 locus are primarily linked to cancer-related traits through population-level genetic association research. The dataset on file spans 211 variants, with cancer as the dominant trait theme across the catalog.

Key takeaways

• Two variants at this locus carry the highest association magnitudes (4.50) among all entries in the gene's catalog.
• Cancer is the primary trait linked to this gene's variant set.
• 211 total variants are on file, with 19 carrying prior published research summaries.
• All signals here are population-level statistical associations, not individual risk predictions.
• Detailed effect sizes and multi-cohort replication data are limited in the current dataset.

Notable variants

The two strongest signals at this locus are rs113752529 and rs567366010, each reaching an association magnitude of 4.50. Of these, rs113752529 carries a documented cancer trait annotation. A further cluster of magnitude 3.00 variants - including rs1006654788, rs1014616126, rs1038637817, rs1172892625, and rs1220483660 - represents additional association signals at this locus identified through GWAS (genome-wide association studies - large scans of genetic variation that look for variants statistically linked to traits across thousands of individuals).

Trait associations

Cancer is the primary trait theme across ZFPM1's variant catalog. rs113752529 provides the most directly annotated cancer association at this locus. The broader set of magnitude 3.00 variants - including rs1235528365, rs1238227876, rs1243499022, rs1252076633, and rs1260097239, among others - represent further signals catalogued at this gene, though specific trait annotations for most are not available in the current dataset.

Evidence quality

The strongest documented signal is rs113752529 at magnitude 4.50 with a cancer trait association; rs567366010 matches that magnitude but lacks a trait annotation in the current data. The broader catalog of 211 variants - with 19 carrying prior research summaries - reflects moderate scientific coverage of this locus. Detailed effect sizes such as odds ratios, sample sizes, and multi-cohort replication status are not available for most variants in the current dataset, so all signals here should be read as GWAS-level associations: statistical correlations observed in populations rather than established causal mechanisms.

What this is NOT

These variants are population-level statistical signals from genetic association studies and are not deterministic predictors of any individual's health outcomes. This page does not constitute medical advice, a diagnosis, or a treatment recommendation.