ZFHX3, variants, traits, and what the research shows

ZFHX3 - what this gene does

Variants catalogued at the ZFHX3 locus are linked predominantly to rare disease trait categories, with one high-magnitude variant also flagged under a cancer-related category.

Key takeaways

• Most of the highest-priority variants at this locus fall under rare disease trait categories.
• One variant, rs727502780, carries a magnitude-5.5 signal linked to cancer.
• A total of 380 genetic variants are on file at this locus, with 20 carrying the highest research priority scores.
• No individual variant research summaries are currently available, so trait details remain at the category level.
• These variants represent population-level statistical signals, not individual predictions.

Notable variants

Among the top-priority variants on file, rs140855443, rs143351192, rs147679383, rs148383343, rs372337934, rs543893560, and rs62639993 each carry a magnitude score of 5.5 and are catalogued under rare disease categories. rs727502780 stands apart as the only variant at this magnitude level catalogued under a cancer-related category.

Trait associations

The dominant trait theme across this gene's on-file variants is rare disease. Twelve of the thirteen magnitude-5.5 variants, including rs140855443, rs143351192, rs147679383, rs148383343, rs2507571642, rs372337934, rs543893560, rs569425024, rs62639993, rs62640000, rs755516522, and rs762302068, are catalogued under rare disease. The remaining magnitude-5.5 entry, rs727502780, falls under cancer. Seven additional magnitude-5.0 variants, including rs2038723552, rs775876705, and rs869312913, also carry rare disease associations.

Evidence quality

No individual study summaries, odds ratios, sample sizes, or replication details are available for any of the 20 top-priority variants at this locus. All trait labels are drawn from research metadata categories rather than from specific published study results. The evidence base at this gene cannot yet be characterized in terms of GWAS (genome-wide association studies, which scan many people's genomes for variants statistically linked to traits) sample sizes or replication status. Readers should treat these associations as pointers to ongoing or forthcoming research rather than as established clinical findings.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors of any individual's health outcomes. This page does not prescribe, diagnose, recommend, or advise any course of action.