ZFAT, variants, traits, and what the research shows

ZFAT - what this gene does

ZFAT appears in population genomics research - studies that scan many people's genomes for variants statistically associated with traits - primarily in connection with rare disease, cardiovascular, cancer, and hormonal trait categories, based on the variants currently on file.

Key takeaways

• The highest-magnitude variant on file is linked to a rare disease trait and represents the strongest signal in this gene's catalog
• Cardiovascular trait associations are present among the top-tier variants
• Cancer-related signals appear at the same magnitude tier as cardiovascular signals
• A hormonal trait signal adds a fourth category of association
• All signals here are population-level statistical findings, not individual health predictions

Notable variants

The strongest signal on file is rs199724546 (magnitude 5.50), associated with a rare disease trait. At the next tier, rs2277138 (magnitude 4.50) is linked to cardiovascular traits and rs6981994 (magnitude 4.50) is linked to cancer. A second magnitude 4.50 variant, rs17768250, appears in the catalog without a specific trait label on file. Among the magnitude 3.00 variants, rs1428157950 carries a hormonal trait association.

Trait associations

Based on the variants catalogued, this gene intersects with four broad trait categories. A rare disease signal is anchored by rs199724546. Cardiovascular associations appear through rs2277138. Cancer-related associations are represented by rs6981994. A hormonal category signal is present via rs1428157950. Several additional magnitude 3.00 variants - including rs1016867047, rs1018441576, and rs138033806 - carry no trait labels in the current dataset, suggesting the gene's full association profile may extend beyond the four labeled categories.

Evidence quality

No prior research summaries are available for any variant in this gene's catalog of 177 variants. Effect sizes such as odds ratios or beta coefficients, sample sizes, and replication status are not present in the input data. The top-magnitude variant, rs199724546 at magnitude 5.50, represents the strongest signal on file, but without underlying study metadata no claims about cohort size or replication status can be made. All associations here should be treated as preliminary until confirmed by independent cohorts.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual person. This content does not constitute medical advice, a diagnosis, or a recommendation for any clinical action.