WT1-AS, variants, traits, and what the research shows

WT1-AS - what this gene does

WT1-AS is a gene whose variants have been statistically linked - in population-level studies - to respiratory conditions, rare diseases, cancer, and metabolic traits.

Key takeaways

• The top variant in this gene is linked to a respiratory trait at the highest magnitude in the dataset.
• Two separate variants independently point to rare disease associations, modestly reinforcing that theme.
• Cancer and metabolic trait associations are also on record, broadening this gene's known landscape.
• 83 variants are catalogued in total, though most lack detailed trait labels in the current data.
• All associations are population-level statistics, not personal health predictions.

Notable variants

The highest-magnitude variant on file is rs78531912 (magnitude 4.50), linked to a respiratory trait - this signal stands noticeably above the rest of the catalog. Two variants associated with rare disease, rs7105159 and rs72905083, each sit at magnitude 2.80, representing the next-strongest tier. Among the large group of magnitude-2.20 variants, rs10835920 is flagged for cancer and rs11031791 for metabolic traits; additional variants at the same magnitude - including rs10160794, rs10219425, rs10767939, rs10767941, rs10835911, and rs10835912 - have published pages but no specific trait labels available in the current dataset.

Trait associations

The primary trait themes across this gene's variant catalog are respiratory conditions and rare diseases. rs78531912 represents the respiratory signal at the highest magnitude on record here. Rare disease associations appear at two independent genome positions, rs7105159 and rs72905083, which modestly reinforces that theme - two independent variants pointing to the same broad category is stronger than a single hit alone. A cancer association is noted at rs10835920 and a metabolic association at rs11031791; each is currently a single variant without additional replication recorded in this dataset.

Evidence quality

The catalog holds 83 variants total, with 27 carrying prior research summaries. The top signal, rs78531912 at magnitude 4.50, stands apart from the rest; its respiratory association is the best-evidenced claim available here. The rare disease signals at magnitude 2.80 - rs7105159 and rs72905083 - gain modest credibility from appearing in two independent variants. The bulk of the catalog clusters at magnitude 2.20 with limited trait annotation, and detailed study metadata such as odds ratios (a measure of how much a variant changes the odds of a trait), beta coefficients, and sample sizes are not available for most entries in the current input. All signals should be treated as preliminary GWAS (genome-wide association study - a scan of many people's genomes for variants statistically linked to a trait) hits until further replication data is available.

What this is NOT

The variants catalogued here are population-level statistical signals drawn from large genome-wide studies; they describe tendencies across groups of people and are not deterministic predictors of any outcome for any individual. This entry does not constitute medical advice, a diagnosis, or a recommendation of any kind.