WDR72, variants, traits, and what the research shows

WDR72 - what this gene does

WDR72 (WD repeat domain 72) has a variant catalog that clusters around two trait themes visible in genomic databases: rare disease and kidney-related conditions. No functional study summaries are currently available for the variants on file, so this entry characterizes the gene by the trait patterns its variants point to.

Key takeaways

• WDR72 variants are most frequently flagged in rare disease trait categories, with 17 of the 20 highest-priority variants carrying that label.
• Three variants are specifically linked to kidney-related traits, forming a secondary signal cluster.
• Several variants reach a magnitude score of 5.50, the highest tier in this gene's current catalog.
• 290 total variants are on file, with 17 carrying research-level annotations.
• These associations are population-level statistical signals, not individual health predictions.

Notable variants

The highest-magnitude rare disease signals include rs1266819147, rs12905755, rs17630660, rs57737580, and rs267607178, all reaching a magnitude of 5.50. Kidney-linked variants at the same tier include rs606231351 and rs768446132, with rs1469562355 adding a kidney signal at magnitude 5.00.

Trait associations

Rare disease is the dominant trait theme across this gene's variant catalog. In addition to those cited above, rs138509133, rs138555114, rs143816093, rs144767107, rs148643501, rs150548151, rs2542089179, rs2543070545, rs606231462, rs764406738, rs142154661, and rs1431736022 are all tagged with rare disease associations. Kidney-related traits appear as a secondary cluster, represented by three variants spread across two magnitude tiers (5.50 and 5.00), which suggests some consistency in that association within the available data.

Evidence quality

No detailed study summaries are available for the 17 annotated variants in the current catalog, meaning sample sizes, odds ratios (a measure of how much a variant changes the statistical likelihood of a trait across a population), beta coefficients (a measure of effect size for continuous traits), replication status, and cohort details cannot be reported here. Magnitude scores of 5.00 to 5.50 reflect a combined ranking of effect size and evidence strength within this database, but without underlying metadata it is not possible to confirm whether findings come from large replicated GWAS studies (genome-wide association studies, which scan large numbers of people's DNA for variants statistically linked to traits) or smaller single-cohort analyses. All associations should be treated as preliminary pointers to areas of genomic research rather than established conclusions.

What this is NOT

These variants are population-level statistical signals derived from genomic studies, not deterministic predictors of any individual's health or disease risk. This page is informational only and does not constitute medical advice, diagnosis, or any form of clinical recommendation.