VTI1A, variants, traits, and what the research shows

VTI1A - what this gene does

Research has identified variants in VTI1A across trait themes that include immune function, cancer, cardiovascular health, neurological conditions, metabolic processes, sleep, mental health, and pharmacogenomics (how an individual's genetic makeup influences their response to drugs). The 82 variants on file span a wide landscape, suggesting this gene intersects multiple biological systems - though the mechanistic details behind each association require further research to characterize.

Key takeaways

• VTI1A carries two of the highest-magnitude variants in this dataset, both at 4.5, linked to immune function and an as-yet-uncharacterized trait respectively
• Cancer associations appear across at least four independent variants, a recurring signal that may strengthen as replication accumulates
• Additional signals span cardiovascular health, neurological conditions, metabolic traits, sleep, mental health, and drug response
• All findings described here come from population-level genome-wide association studies - they reflect statistical patterns across large groups, not certainties for any individual
• Several variants have published research pages, indicating sustained scientific attention

Notable variants

The two highest-magnitude signals are rs147585669 (magnitude 4.5, linked to immune traits) and rs540416829 (magnitude 4.5, trait uncharacterized in available data). A step below, rs2133836443 (magnitude 3.0) is associated with cancer. Three additional variants at magnitude 2.8 also carry cancer associations: rs11196063 and rs7086803. Rounding out the 2.8-magnitude tier, rs11196078 is linked to cardiovascular traits, rs143849308 to pharmacogenomics, and rs17266687 to mental health.

Trait associations

The broadest cluster centers on cancer, where rs2133836443, rs11196063, rs7086803, and rs10506868 all point in this direction - four independent variants sharing a trait theme is a signal worth tracking as replication studies accumulate. Immune function is flagged by rs147585669 at the highest magnitude in the dataset. Cardiovascular associations appear via rs11196078; neurological via rs1033922; metabolic via rs10787461; sleep via rs7071256; mental health via rs17266687; and pharmacogenomics via rs143849308.

Evidence quality

The strongest signals reach magnitude 4.5, and five variants - rs11196063, rs11196078, rs10506868, rs10787461, and rs1033922 - have dedicated published research pages, indicating they have attracted enough scientific attention to warrant individual documentation. Detailed summaries for those entries were not available at time of writing, so specific effect sizes, sample sizes, and replication status cannot be reported here. The remaining variants are catalogued from GWAS - genome-wide association studies, which scan large populations for statistical links between genetic markers and traits - and carry the standard caveat that GWAS hits, particularly early or single-cohort findings, may not replicate universally.

What this is NOT

The variants described here are population-level statistical associations - they describe patterns observed across many people and carry no deterministic meaning for any single individual. This page does not prescribe, diagnose, or advise any course of action.