UBASH3B, variants, traits, and what the research shows

UBASH3B - what this gene does

Variants in UBASH3B have appeared in genome-wide association studies (GWAS - studies that scan large populations for genetic variants statistically associated with a trait) linking this gene to liver, neurological, and immune-related traits. The specific biological mechanism cannot be characterized here beyond those trait themes, as the available summaries do not include mechanistic or functional detail.

Key takeaways

• This gene has variants associated with liver, neurological, and immune traits in population genetics research.
• Five variants reach the highest magnitude score in this dataset (4.50), indicating stronger statistical associations relative to the rest.
• 83 variants are catalogued at this locus, though most lack detailed trait annotations in the current data.
• These associations are population-level statistical signals, not individual health predictors.
• Sample sizes and effect sizes such as odds ratios are not available in the current summaries, so all findings should be treated as preliminary.

Notable variants

The five variants carrying the highest magnitude scores (4.50) are rs10790528, linked to a liver-related trait; rs191973044, linked to a neurological trait; and rs57213254, linked to an immune trait. rs35324392 and rs4935805 also reach a magnitude of 4.50, though no trait annotation is currently on file for either. A broader set of lower-magnitude variants at score 3.00 - including rs1044981494, rs138863082, and rs373182486 - rounds out the catalogued signal landscape, though trait details for these are not available.

Trait associations

The available data links this gene to three trait domains. A liver-related trait is associated with rs10790528. A neurological trait is associated with rs191973044. An immune-related trait is associated with rs57213254. No trait annotations are recorded for rs35324392 or rs4935805, and the majority of the magnitude-3.00 variants also lack trait metadata, so the full breadth of associations at this locus is likely wider than what is captured here.

Evidence quality

The five magnitude-4.50 variants represent the strongest signals in the current dataset. However, specific study metadata - including sample sizes, cohort replication counts, and effect sizes such as odds ratios or beta coefficients - is absent from the available summaries, making it impossible to fully assess how robust any individual association is. Only 17 of the 83 catalogued variants have prior research summaries, meaning the trait picture for most variants remains uncharacterized. All findings here should be treated as preliminary GWAS signals pending replication in independent cohorts with published effect sizes.

What this is NOT

The variants listed here are population-level statistical associations and do not determine or predict any individual person's health outcomes. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.