TNXB, variants, traits, and what the research shows

TNXB - what this gene does

Based on the variants catalogued for TNXB, this gene's research associations cluster around two primary trait themes: cardiovascular conditions and musculoskeletal conditions. One variant in the highlighted set also falls under a rare disease classification, indicating the gene's documented associations extend across multiple domains.

Key takeaways

• The overwhelming majority of the top-ranked variants in this gene are linked to cardiovascular traits.
• A musculoskeletal association is also represented in the variant data.
• At least one variant is classified under a rare disease research category.
• All 20 highlighted variants share a magnitude score of 5.50, a measure of the assessed significance of a variant's research association.
• These are population-level statistical signals - not individual health predictions.

Notable variants

All 20 highlighted variants carry a magnitude score of 5.50. The cardiovascular signal is the most prominent: rs1005686810, rs1179322894, rs121912575, rs138771398, rs140160519, and rs1406340228 are among the cardiovascular-linked variants in this set. The musculoskeletal category is represented by rs1254121532, and rs1352801514 is classified under rare disease associations - the only variant in the highlighted group to carry that label.

Trait associations

Cardiovascular traits dominate the top-ranked variant set: 18 of the 20 highlighted variants carry a cardiovascular label, including rs1188559992, rs1195935577, rs1230512934, rs1304146232, rs1331733789, rs1340605654, rs1349800834, rs1385532203, rs138850364, rs139154852, and rs140665128. The breadth of cardiovascular-labeled variants across this gene suggests it is a recurring target in GWAS (genome-wide association studies - studies that scan many people's genomes for variants statistically associated with a trait) focused on cardiovascular biology. The musculoskeletal signal, represented by rs1254121532, and the rare disease signal from rs1352801514, indicate the gene's research footprint extends beyond a single trait domain.

Evidence quality

The current catalog lists 1,434 total variants for this gene, of which 20 have been highlighted with trait-level annotations and magnitude scores. Detailed per-study metadata - including sample sizes, odds ratios, beta coefficients, and replication cohort information - is not yet available for any of the 20 highlighted variants. All 20 share a uniform magnitude score of 5.50, which prevents prioritizing one over another on evidence grounds alone. Until study-level summaries are published for these variants, readers should treat these trait associations as preliminary research signals rather than replicated, well-characterized findings.

What this is NOT

The variants listed here are population-level statistical associations - signals that a given allele appears more often alongside a particular trait across a study population - not deterministic predictions for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.