TNFSF4, variants, traits, and what the research shows

TNFSF4 - what this gene does

TNFSF4 is a human gene whose variants, based on the data on file, are predominantly associated with immune-related traits, with additional associations in rare disease and sleep categories.

Key takeaways

• The majority of TNFSF4 variants catalogued are linked to immune-related traits.
• Three variants reach the highest magnitude on file (4.50): two in immune traits and one in a rare disease category.
• A single variant is associated with sleep, extending documented associations beyond immunity.
• 67 total variants are on file for this gene, with 17 carrying prior research summaries.
• These are population-level statistical associations, not individual-level predictions.

Notable variants

The three highest-magnitude variants (4.50) are rs12736195 and rs76413021, both linked to immune traits, and rs561708165, linked to a rare disease category. At magnitude 3.00, four variants - rs146261831, rs2525728080, rs566629355, and rs745541182 - are on file without specific trait labels attached. A cluster at magnitude 2.80 includes rs10753074, rs10798269, rs10912578, and rs1234315, all linked to immune traits and each with a published research summary.

Trait associations

Immune-related traits dominate the variant landscape of this gene. Variants at multiple magnitude levels - rs12736195, rs76413021, rs10753074, rs10798269, rs10912578, rs1234315, rs2039982, rs2205960, rs4916209, rs4916342, rs61828284, rs6681482, and rs704840 - all carry immune trait labels, suggesting a consistent signal across the gene. A rare disease association is represented by rs561708165. A separate sleep association is documented for rs7553711.

Evidence quality

67 variants are catalogued for this gene, of which 17 have prior research summaries. Four variants - rs10753074, rs10798269, rs10912578, and rs1234315 - have published pages with detailed findings. The three highest-magnitude variants (rs12736195, rs561708165, rs76413021) score 4.50, the highest on file for this gene, but specific study designs, sample sizes, and replication status are not included in the current dataset for those entries. The breadth of immune-trait associations across 13 variants at multiple magnitude levels may indicate a replicated regional signal, but individual variant pages should be consulted before drawing conclusions.

What this is NOT

The variants listed here are population-level statistical associations identified in genome-wide association studies (GWAS - studies that scan many people's genomes for variants statistically linked to a trait), and they do not predict any individual's health outcomes with certainty. This page does not prescribe, diagnose, or recommend any action.