TENM4, variants, traits, and what the research shows

TENM4 - what this gene does

The catalogued variants for TENM4 all cluster within a single trait theme: rare disease. Without published summaries for the individual variants on file, the data point consistently to rare disease phenotypes across 20 high-magnitude entries, making this the defining signal currently available for this gene.

Key takeaways

• All 20 high-magnitude TENM4 variants on file are linked to rare disease phenotypes - no common complex traits appear in the current dataset.
• The top 19 variants each carry a magnitude score of 5.50, indicating consistently strong effect sizes within this trait category.
• Without individual variant summaries, the specific conditions involved cannot be confirmed from this dataset alone.
• These are population-level statistical associations, not deterministic predictions for any individual.
• TENM4 has 333 catalogued variants in total, with rare disease as the dominant trait theme among the highest-magnitude entries.

Notable variants

The highest-magnitude entries - each scoring 5.50 - include rs141706152, rs191549326, rs199687168, rs199909021, and rs199973967, all associated with rare disease. Several additional variants at the same magnitude tier reinforce this signal, including rs200271895, rs201191369, and rs201960718. One further variant, rs1555080708, registers at a magnitude of 5.00 within the same rare disease category.

Trait associations

Every variant with a catalogued trait in this gene is associated with rare disease. This concentration of signal across 20 high-magnitude variants - all pointing to the same broad trait category - distinguishes this gene from those whose variant profiles span multiple unrelated trait domains. However, the specific rare disease diagnoses or phenotypes linked to individual variants are not documented in the current dataset, so the exact conditions involved remain unclear from this source alone. The recurrence of the rare disease signal across many independent variants does strengthen the overall association, even in the absence of per-variant clinical detail.

Evidence quality

Individual variant summaries are not yet available for this gene, and specific details such as sample sizes, odds ratios, cohort descriptions, and replication status are absent from the current data. The magnitude scores indicate notable effect sizes relative to typical genome-wide association study (GWAS - a study that scans large groups of people for genetic variants statistically associated with a trait) hits, but without cohort-level details or replication counts, all signals here should be treated as preliminary. Readers seeking clinical or mechanistic context should consult primary literature directly.

What this is NOT

These variants are population-level statistical signals from GWAS and similar sources, not deterministic predictors of any disease outcome for any individual. This entry does not constitute medical advice, a diagnosis, or a recommendation of any kind.