TEAD1, variants, traits, and what the research shows

TEAD1 - what this gene does

Variants catalogued for TEAD1 span several distinct trait themes - vision conditions, rare diseases, cancer, neurological traits, and respiratory conditions - suggesting this gene may be relevant across multiple biological systems. No individual variant research summaries are currently available, so the picture below is drawn entirely from the variant list and its trait labels.

Key takeaways

• The two highest-magnitude variants are linked to vision and rare disease traits
• Additional high-magnitude variants point to cancer, neurological conditions, and respiratory traits
• Rare disease appears across multiple separate variants, suggesting repeated research interest in this locus
• 179 variants are catalogued for this gene, with 6 carrying magnitude scores of 4.5 or higher
• All associations are population-level statistical signals, not predictors of individual outcomes

Notable variants

The two highest-scoring variants are rs11567847 (magnitude 5.50, vision) and rs746873807 (magnitude 5.50, rare disease). Four additional variants reach magnitude 4.50: rs150439061 is catalogued under cancer, rs3890065 under neurological traits, rs7102432 under respiratory traits, and rs4757965 carries a 4.50 magnitude score without a currently catalogued trait label. Below these, a cluster of magnitude-3.00 variants includes several flagged for rare disease: rs1006859684, rs1040999399, and rs1308853181.

Trait associations

Trait coverage across this gene's variant set is notably broad. Vision appears as the top-ranked trait, represented by rs11567847 at the highest magnitude tier. Rare disease is the most recurrent theme: rs746873807 also reaches the highest magnitude tier, and rare-disease associations reappear independently at lower magnitudes in rs1006859684, rs1040999399, and rs1308853181 - the appearance of the same trait across multiple distinct variants is generally considered a signal worth noting in GWAS (genome-wide association study - a method that scans many people's genomes for variants statistically associated with a trait) research. Cancer (rs150439061), neurological conditions (rs3890065), and respiratory traits (rs7102432) each appear once in the mid-magnitude tier.

Evidence quality

No individual variant research summaries are currently available for this gene, so sample sizes, replication status, and study design cannot be assessed at the variant level. Magnitude scores - which combine effect size and evidence strength - reach 5.50 for two variants and 4.50 for four others, indicating that a subset of associations carries relatively stronger signals within this dataset; the remaining 173 catalogued variants cluster at magnitude 3.00 or below. All associations here should be treated as preliminary pointers to the broader research literature rather than confirmed clinical findings; individual variant pages will carry more detailed evidence when summaries become available.

What this is NOT

These variants are population-level statistical signals - they describe patterns observed across large groups of people and are not deterministic predictors of any trait or condition for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.