SUPT3H, variants, traits, and what the research shows

SUPT3H - what this gene does

The variants linked to this gene cluster around two primary trait themes: neurological conditions and respiratory conditions. Of the 138 variants on file, a group of seven carries the highest signal scores in the dataset (a measure used to rank variants by association strength), pointing to multiple strong association signals across both trait categories.

Key takeaways

• SUPT3H has variants linked to both neurological and respiratory trait categories.
• Seven variants share the top signal score in this dataset, suggesting multiple strong association signals.
• The variant rs3799965 is associated with a neurological trait; rs634789 is associated with a respiratory trait.
• 138 total variants are on file, with 18 carrying prior research summaries, meaning most signals have limited published backing at this time.
• These are population-level statistical associations, not individual health predictors.

Notable variants

The seven highest-ranked variants in this gene, rs10456544, rs1284962, rs16872971, rs1797156, rs9395066, rs3799965, and rs634789, all carry the top signal score in the dataset. Among these, rs3799965 is labeled with a neurological trait and rs634789 is labeled with a respiratory trait; the remaining five lack specific trait labels in the current summaries. A second tier of variants including rs113964926, rs150635035, and rs371911961 rounds out the on-file catalog with lower but still notable scores.

Trait associations

The two documented trait themes for this gene are neurological conditions and respiratory conditions. The neurological signal is represented by rs3799965, and the respiratory signal by rs634789, both sitting among the top-ranked variants on file. Multiple additional top-tier variants, rs10456544, rs1284962, rs16872971, rs1797156, and rs9395066, appear at the same signal level without specific trait labels in the current dataset, leaving their precise associations to be documented as research summaries are added.

Evidence quality

Of the 138 variants on file, 18 carry prior research summaries, meaning the large majority of signals lack detailed published backing at this time. Specific effect sizes such as odds ratios or beta coefficients, cohort sample sizes, and replication status are not available in the current summaries for most variants. Without those details it is not possible to confirm whether findings come from large multi-cohort GWAS studies (GWAS stands for genome-wide association study, a method that scans many people's genomes to identify variants statistically linked to a trait) or from smaller, single-cohort preliminary efforts. The two trait-labeled variants, rs3799965 and rs634789, provide the clearest directional signals currently available; all other associations should be treated as preliminary pending fuller evidence summaries.

What this is NOT

The associations listed here are population-level statistical signals observed across large groups of people; they do not predict any outcome for a specific individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any course of action.