SUFU, variants, traits, and what the research shows

SUFU - what this gene does

Variants in SUFU are associated with two broad trait themes - cancer and rare disease - across 782 catalogued entries. With no SNP-level research summaries yet available, the significance of this gene is characterized here through the trait categories its highest-scored variants fall into.

Key takeaways

• SUFU has variants linked to both cancer and rare disease categories
• All top-ranked variants carry an identical high score, indicating consistent research interest across entries
• The variant catalogue is large (782 entries), suggesting this gene recurs as a signal in genetic association studies
• These are population-level statistical associations - they do not predict individual outcomes
• Detailed effect sizes and replication data are not yet available for individual variants in this dataset

Notable variants

The highest-scored variants on file all reach a score of 5.50. Among those linked to cancer: rs1040654062, rs1060501104, rs1060501109, rs137880855, and rs141359583. Variants classified under rare disease at the same score tier include rs1060501103, rs1060501108, and rs1212706214. Both trait categories appear at the same score level, indicating neither dominates the available evidence by ranking alone.

Trait associations

This gene's variant catalogue spans two trait themes. The cancer category accounts for the majority of the 20 top-ranked variants - including rs1060501117, rs1060504147, rs1171604398, rs1244167364, rs1254002019, rs1275187815, rs1342217589, rs141737156, rs142672533, rs143807689, rs144666812, and rs145082320. The rare disease category is represented at the same score tier by rs1060501103, rs1060501108, and rs1212706214. The co-occurrence of both themes across a large catalogue suggests the gene intersects multiple distinct biological contexts.

Evidence quality

All 20 top-ranked variants carry a score of 5.50 - the highest tier on file for this gene - but no SNP-level summaries providing effect sizes, odds ratios, cohort sizes, or replication status are currently available. Of the 782 total variants, only 27 have prior research summaries, a small fraction, meaning the evidence base for most entries remains to be characterized. Without replication or sample size data, the strength of individual associations cannot be assessed here; these findings should be treated as preliminary signals requiring further evaluation.

What this is NOT

These variants are population-level statistical signals from genetic association studies - they are not deterministic predictors of cancer or rare disease for any individual. This page does not prescribe, diagnose, or advise any course of action.