ST3GAL4, variants, traits, and what the research shows

ST3GAL4 - what this gene does

ST3GAL4 has variants that genome-wide association studies (GWAS - research designs that scan hundreds of thousands of genetic positions across large populations to find variants statistically linked to traits) have connected to liver, cardiovascular, and metabolic trait categories. The available variant data is most informative around liver-related signals, with additional observations in cardiovascular and metabolic domains.

Key takeaways

• The two highest-magnitude variants in this gene are linked to liver-related traits, representing the strongest statistical signals in the dataset.
• Separate variants point to cardiovascular and metabolic associations at lower but notable magnitudes.
• 129 variants across this gene are on file, though most lack published trait detail in the current dataset.
• All associations described here come from population-level studies and carry no predictive weight for any individual.
• Replication and sample-size data are not available for most variants in this summary.

Notable variants

The highest-magnitude entries in this gene are rs2236653 and rs73633606, each scoring 4.50 - the strongest signals in the available dataset. rs2236653 is specifically flagged with a liver trait association. A cluster of variants at magnitude 3.00 - including rs1344403853, rs144143100, rs146779997, rs148736743, and rs201196480 - appear in the catalog without published trait detail at this time. Among the magnitude 2.20 tier, rs10790800 carries a cardiovascular association and rs10893499 a metabolic one; rs10790801, rs10790802, rs10893498, and rs10893501 are also catalogued with published pages but no trait detail is currently available in this summary.

Trait associations

Liver function is the dominant trait theme in this gene, anchored by rs2236653 at magnitude 4.50. Cardiovascular traits appear via rs10790800 at magnitude 2.20, and metabolic traits are noted for rs10893499 also at magnitude 2.20. The broader 129-variant catalog includes 28 variants with prior research summaries, but the trait detail available for this summary is limited to those three domains. No single trait is represented by more than one fully characterized variant in the current dataset, so cross-variant replication within this summary cannot be confirmed.

Evidence quality

The strongest signal - rs2236653 at magnitude 4.50 with a liver trait flag - represents the best-evidenced entry in this gene's current catalog. The magnitude 3.00 tier contains 12 variants, none of which have published trait detail in the current dataset; these should be treated as preliminary entries. The magnitude 2.20 variants with cardiovascular and metabolic labels (rs10790800, rs10893499) have published pages, but full sample sizes, effect sizes (odds ratios or beta coefficients measuring how strongly a variant shifts a trait), and replication status are not available in this summary. The most important caveat is that the majority of the 129 catalogued variants in this gene remain uncharacterized in the available data.

What this is NOT

These variants are population-level statistical signals from GWAS research, not deterministic predictors of any individual's liver, cardiovascular, or metabolic outcomes. This content is not medical advice, does not constitute a diagnosis, and should not be used to guide any health-related decisions.