SMARCA4, variants, traits, and what the research shows

SMARCA4 - what this gene does

SMARCA4 (also known as BRG1, SNF2L4, and BAF190B) sits on chromosome 19 and is represented across 2,355 catalogued variants in our database, all of the 20 variants carrying research-level summaries being linked to the broad trait category of cancer. Because no individual SNP-level summaries are yet available for this gene, this entry characterises the gene exclusively through the pattern visible in its variant list - a consistent association with cancer-related phenotypes.

Key takeaways

• Every variant in this gene's reviewed set is linked to cancer, suggesting this locus is primarily flagged in oncology-focused research.
• Twenty variants share an identical magnitude score of 5.50, indicating a uniform evidence tier across the catalogued set rather than one dominant signal standing above the rest.
• With 2,355 total variants on file, only a small fraction have been annotated so far; the full scope of this gene's associations is likely broader than what is currently summarised.
• These are population-level statistical signals from genetic studies - they do not predict cancer in any individual.
• Detailed trait-level interpretation awaits individual SNP summaries, which will be added as they become available.

Notable variants

All twenty variants currently carrying research context share the same magnitude (5.50) and the same broad trait label (cancer), so no single variant stands clearly above the others on available evidence alone. The catalogued set includes rs1016382250, rs1018881303, rs1020163987, rs1021610405, rs1023059961, rs1029640674, rs1050237, rs1055237124, and rs1056234449, among others including rs1057518049, rs1057518862, rs1057520203, rs1057523400, rs1060502057, rs1060502059, rs1060502064, rs1060502082, rs1060502085, rs1060502087, and rs1060502089. Each carries the same evidence tier; none can be elevated above the others on the data currently available.

Trait associations

Every variant in the reviewed set is linked to the trait label cancer. The consistency of this single trait label across all twenty entries - rather than a mix of unrelated conditions - indicates that this gene surfaces repeatedly within oncology research contexts. However, because no SNP-level summaries have yet been written, the specific cancer subtypes, direction of effect, odds ratios, and study cohorts behind each association are not yet resolvable from the available data. As individual SNP pages are completed, this section will be updated with trait-specific detail.

Evidence quality

The current evidence base for this gene is uniform in tier (magnitude 5.50 across all reviewed variants) but thin in interpretable detail: no SNP summaries have been published yet, leaving the underlying study types, sample sizes, replication status, and effect-size estimates unavailable for review. The fact that all annotated variants point to a single broad trait - cancer - is consistent with a gene that is studied primarily in oncological contexts, but without individual study metadata it is not possible to distinguish well-replicated multi-cohort signals from preliminary single-study findings. Users should treat all claims at this stage as provisional pending full SNP annotation.

What this is NOT

The variants documented here are population-level statistical associations - they describe patterns observed across large groups of people and carry no deterministic meaning for any single individual's health trajectory. This entry does not constitute medical advice, a diagnosis, or a recommendation of any kind.