SLC38A4-AS1, variants, traits, and what the research shows

SLC38A4-AS1 - what this gene does

SLC38A4-AS1 is a gene whose catalogued variants connect to a range of trait themes including respiratory health, immune function, musculoskeletal conditions, liver biology, metabolic markers, and blood coagulation. No functional mechanism is available in the current dataset, so this entry describes only what the variant associations reveal.

Key takeaways

• Variants near this gene are associated with six distinct trait themes: respiratory, immune, musculoskeletal, liver, metabolic, and coagulation.
• The highest-magnitude signals (magnitude 4.50) involve respiratory and immune trait categories.
• Two coagulation-linked variants appear together in the dataset, which may reflect a shared regional genomic signal.
• Liver and metabolic associations each appear in at least one catalogued variant.
• All findings are population-level statistical associations, not deterministic predictions for any individual.

Notable variants

The four variants carrying the highest magnitude score (4.50) are rs1125909, linked to a respiratory trait; rs946174353, linked to an immune trait; and rs2465216 and rs7312259, which share the same magnitude tier but have no specific trait assigned in the current records. At magnitude 2.80, rs2408618 is the sole musculoskeletal signal in the set. Among the magnitude 2.20 variants, rs12579903 and rs12582034 both carry coagulation-linked signals and may represent overlapping biology at this locus. rs111621504 contributes a liver-related association, and rs118080406 adds a metabolic signal to the picture.

Trait associations

Respiratory traits appear at the top of the evidence tier via rs1125909. Immune-related associations surface through rs946174353, also at the highest magnitude in this dataset. Musculoskeletal traits connect through rs2408618. Liver-related traits link to rs111621504, and metabolic traits to rs118080406. Notably, both rs12579903 and rs12582034 are catalogued under coagulation - when two nearby variants share a trait theme it can suggest a regional signal, though replication data is not available here to confirm that interpretation. The remaining magnitude 2.20 variants on file do not carry assigned trait labels in the current records.

Evidence quality

The full dataset for this gene contains 67 catalogued variants, 16 of which have published editorial summaries. The strongest signals sit at magnitude 4.50, with one intermediate signal at 2.80 and a larger cluster at 2.20. All associations are drawn from GWAS (genome-wide association studies - large scans of many people's genomes for variants statistically linked to a trait) findings, which capture population-level correlations rather than confirmed causal mechanisms. No sample sizes, effect sizes such as odds ratios or beta coefficients, or replication cohort details are present in the available data, which limits independent assessment of signal robustness. The breadth of trait themes across six biological domains is notable but should be interpreted cautiously until further study-level metadata is incorporated.

What this is NOT

These variants are population-level statistical signals from large genomic studies, not deterministic predictors of any health outcome for any individual. This content is informational only - we do not prescribe, diagnose, or advise on any course of action.