SLC14A2, variants, traits, and what the research shows

SLC14A2 - what this gene does

Based on the available variant data, SLC14A2 is a gene with associations spanning multiple trait domains, including cardiovascular conditions, neurological traits, mental health, rare disease, and cancer. The specific biological mechanisms behind these associations are not characterized in the evidence currently on file.

Key takeaways

• This gene has 152 variants on file, with the strongest signals spanning cardiovascular, neurological, and mental health domains
• The top-ranked variants all reach a magnitude of 4.50, the highest tier in this dataset
• Two variants - one linked to rare disease and one to cardiovascular traits - have dedicated published research pages
• All associations come from GWAS (genome-wide association studies - research that scans many people's genomes for variants statistically linked to a trait) and should be treated as population-level signals, not individual predictions
• Evidence depth is uneven: most of the 152 variants on file lack published summaries on this platform

Notable variants

The strongest signals on file cluster around ten variants all reaching magnitude 4.50. rs11082436 is linked to a rare disease trait, and rs11659929 is associated with cardiovascular conditions - both carry dedicated published research pages. Two neurological associations appear at this top tier: rs142988207 and rs8091629. Mental health signals are represented by rs7229439 and rs9954874. rs190330880 is linked to cancer, and rs79284447 represents a second cardiovascular signal. Two additional top-tier variants - rs2243803 and rs2852306 - do not have trait labels on file.

Trait associations

The variant data covers five broad domains. Cardiovascular associations appear in at least two top-tier variants (rs11659929 and rs79284447), a repeated signal that reinforces the cardiovascular theme. Neurological traits are represented by rs142988207 and rs8091629. Mental health traits show up in both rs7229439 and rs9954874. Rare disease and cancer each appear in one top-tier variant - rs11082436 and rs190330880, respectively. Beyond the top ten, 142 additional variants are on file spanning the same trait categories at lower magnitude scores.

Evidence quality

rs11082436 and rs11659929 are the best-documented signals on this platform, each with a dedicated published research page. The remaining high-magnitude variants and the large majority of the 152 total variants on file lack published editorial summaries, meaning the full trait picture remains incompletely characterized here. All signals should be treated as GWAS associations - statistically observed in research populations - until replication across independent cohorts is established.

What this is NOT

These variants represent population-level statistical associations from research studies, not deterministic predictors of any condition or outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any course of action.