SHTN1, variants, traits, and what the research shows

SHTN1 - what this gene does

Based on catalogued variant data, SHTN1 has been linked to neurological and metabolic trait categories through genetic association research (GWAS - genome-wide association studies that scan many people's genomes for variants statistically associated with a trait). No additional functional description is available from the research summaries on file.

Key takeaways

• Six variants in this gene reach the highest evidence level in the current data set, each carrying a magnitude score of 4.50.
• One high-magnitude variant is associated with neurological traits and another with metabolic traits.
• 58 variants are catalogued for this gene in total, with 19 carrying prior published research.
• All associations here are population-level statistical signals from large group studies, not personal health predictions.
• Specific trait detail for several top variants is not yet available in the current data.

Notable variants

Six variants reach magnitude 4.50, the highest tier on file: rs10510026, rs11197863, rs1122688, rs11528300, rs4638225, and rs7902527. Of these, rs11197863 has a documented neurological trait association, and rs1122688 has a documented metabolic trait association. Both rs10510026 and rs11528300 have published research pages, though their specific trait labels are not yet documented in the available data. A group of lower-magnitude variants at 3.00 rounds out the catalogue, including rs1025931260, rs1847748864, rs200045766, rs2133286684, and rs368351085, among others.

Trait associations

Two trait categories have been identified in the available data: neurological and metabolic. The neurological signal is documented via rs11197863 (magnitude 4.50), and the metabolic signal via rs1122688 (magnitude 4.50). Both reach the highest evidence tier on file. The four remaining high-magnitude variants, rs10510026, rs11528300, rs4638225, and rs7902527, share the same magnitude level but have not been assigned specific trait labels in the current data.

Evidence quality

Of the 58 variants catalogued for this gene, 19 carry prior published research summaries, indicating moderate existing coverage. The top magnitude tier (4.50) includes six variants, reflecting strong individual evidence scores, though raw effect sizes such as odds ratios or beta coefficients (numerical measures of how much a variant shifts a trait or risk level) were not supplied in the available input. Specific trait labels are confirmed for only two variants. The full breadth of associations for this gene remains incompletely described, and all signals here should be treated as preliminary pending more complete data integration.

What this is NOT

These variants are population-level statistical signals from association studies - they are not deterministic predictors of any condition for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any action.