SHROOM3, variants, traits, and what the research shows

SHROOM3 - what this gene does

SHROOM3 is a human gene whose catalogued variants point primarily to cardiovascular traits. Based on available variant metadata, the gene's most notable associations fall within the cardiovascular category.

Key takeaways

• This gene has 206 catalogued variants, with the highest-magnitude signals linked to cardiovascular traits.
• The four top-magnitude variants each carry a magnitude rating of 4.50, the strongest level recorded for this gene.
• Most catalogued variants carry a magnitude of 3.00, indicating moderate evidence strength.
• These are population-level statistical associations from genome-wide studies, not individual health predictors.
• Only a subset of variants currently have published research summaries, so the full picture is still emerging.

Notable variants

The highest-magnitude variants on file are rs11730486, rs139442711, rs1398016, and rs4544731, each rated at magnitude 4.50. Of these, rs11730486 carries an explicit cardiovascular trait tag and has a dedicated published page. The remaining three magnitude 4.50 variants - rs139442711, rs1398016, and rs4544731 - do not yet have published trait details in the current dataset. Among the magnitude 3.00 variants, rs1041451291, rs1049485785, rs111815461, and rs1183430270 represent part of a broader group of signals catalogued for this gene.

Trait associations

The primary documented trait theme across this gene's variants is cardiovascular. rs11730486 is the one variant in the current dataset with a named cardiovascular trait association at the highest observed magnitude (4.50). The three other top-magnitude variants - rs139442711, rs1398016, and rs4544731 - lack published trait detail in the current dataset, so no additional trait claims can be made for them at this time.

Evidence quality

rs11730486 represents the best-documented signal in this dataset, carrying a magnitude of 4.50 with a cardiovascular trait association and a dedicated published page. Three additional variants - rs139442711, rs1398016, and rs4544731 - share the same magnitude rating but have no published trait metadata available here. Of 206 total variants on file, 17 carry prior research summaries, and only one has a fully published editorial page. The majority of catalogued variants are rated at magnitude 3.00 and currently lack detailed published summaries. The full trait picture for this gene remains incomplete in this dataset, and findings should be treated as preliminary until further replication data is available.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies, which scan large groups of people's genomes for variants statistically linked to traits), not deterministic predictors for any individual. This content is informational only; we do not prescribe, diagnose, or advise any course of action.