SGCZ, variants, traits, and what the research shows

SGCZ - what this gene does

SGCZ is a human gene whose variants appear in genetic research linking it to mental health and neurological traits. The associations on file cluster into those two domains, based on the 159 variants currently tracked.

Key takeaways

• This gene carries multiple variants associated with both mental health and neurological traits
• The top-ranked variants reach a magnitude score of 4.50, spanning both trait categories
• 159 variants are tracked in this gene, with 16 carrying prior published research context
• Multiple independent variants converge on the same trait domains, reinforcing the association signal
• These are population-level statistical associations, not individual predictions for any person

Notable variants

The highest-magnitude variants on file all score 4.50. Among those with mental health associations, rs10089596 and rs116939006, both of which have dedicated research pages, stand out alongside rs146790986 and rs78076666. On the neurological side, rs7010173, rs35521161, rs12675921, and rs12682628 each reach the same magnitude tier. Additional top-magnitude variants, including rs13261120, rs4427170, and rs7814925, are catalogued without specific trait labels in the current data.

Trait associations

Two trait domains emerge from the variant data: mental health and neurological traits. Both are supported by multiple top-magnitude variants, which adds to the association signal compared to a single-variant finding. Mental health associations reach the 4.50 magnitude tier across rs10089596 and rs116939006, among others, while neurological associations reach the same tier across rs7010173 and rs12682628, among others. More granular trait labels within either domain are not included in the current data set.

Evidence quality

The evidence on file consists of GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) signals, with the top tier reaching a magnitude of 4.50. A total of 159 variants are tracked, 16 of which carry prior research context. The available data does not include sample sizes, odds ratios, or beta coefficients for individual variants, which limits precise characterization of effect sizes. Replication across independent cohorts is not documented in the current summaries, and several top-magnitude variants lack specific trait labels, so confidence in any single variant signal should be calibrated with care.

What this is NOT

These variants represent population-level statistical signals from genetic research studies, not deterministic predictions for any individual person. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.