SCMH1-DT, variants, traits, and what the research shows

SCMH1-DT - what this gene does

SCMH1-DT has 42 documented variants with trait associations spanning neurological conditions, mental health phenotypes, and vision-related traits. The available summaries do not supply molecular function details, so the description below reflects only the trait themes visible in variant-level research metadata.

Key takeaways

• SCMH1-DT carries 42 documented variants, with the two strongest signals reaching a magnitude of 4.50.
• Six variants in this gene are tagged to neurological trait categories, making that the most represented theme.
• Three variants carry mental health associations, and one is linked to a vision-related trait.
• All signals come from population-level genome-wide association studies and are not deterministic predictions for any individual.
• Detailed effect sizes and replication data are limited in current summaries; treat all signals as preliminary.

Notable variants

The two highest-magnitude variants on file are rs12036554 and rs12744310, both at magnitude 4.50, with rs12744310 tagged to a neurological trait. A cluster of variants at magnitude 2.20 adds further coverage: rs11209894, rs12030183, rs12043581, and rs1343775 all carry neurological labels, while rs12025777 and rs12035012 are linked to mental health phenotypes. rs12026778 stands out as the sole variant with a vision association in the current dataset.

Trait associations

Neurological conditions represent the most common trait theme, with six variants carrying that label: rs12744310, rs11209894, rs12030183, rs12043581, rs1343775, and rs16828019. Mental health phenotypes appear across three variants, rs12025777, rs12035012, and rs12751511, suggesting a recurring association rather than an isolated signal. Vision traits are represented by rs12026778, and nutrition by rs1343776. Several additional variants, including rs11209838, rs11209839, rs12143111, rs12144763, and rs113414761, do not carry trait labels in the current dataset.

Evidence quality

The strongest signals, rs12036554 and rs12744310 at magnitude 4.50, represent the most compelling starting points; however, full effect sizes, sample sizes, and replication cohort details are not available in the current summaries. The remaining variants at magnitude 2.20 are consistent with modest GWAS (genome-wide association study, a study that scans large numbers of people's genomes for variants statistically linked to a trait) hits, which are common findings that typically require replication in independent cohorts before conclusions can be drawn. Without complete cohort details or multi-study confirmation for most variants here, all associations should be treated as preliminary.

What this is NOT

These variants are population-level statistical signals derived from group studies, not deterministic predictors for any individual's health outcomes. This page does not prescribe, diagnose, or advise any medical course of action.