RUNX1, variants, traits, and what the research shows

RUNX1 - what this gene does

Variants in RUNX1 (located at chromosomal region 21q22.12) are linked exclusively to cancer across all characterized positions in the current variant record. Because no prior SNP-level research summaries are on file for this gene, this entry describes the trait signals visible in the variant list rather than any underlying molecular mechanism.

Key takeaways

• All 20 top-ranked RUNX1 variants carry a cancer trait association at the same magnitude score (5.50), suggesting a concentrated signal at this locus
• A total of 931 variants have been catalogued here, indicating substantial genomic research interest in this gene
• No specific cancer subtype information is available from the current variant data
• Without study-level data - sample sizes, odds ratios, replication cohorts - the strength of individual signals cannot be fully assessed
• These are statistical associations from population-level research, not personal risk predictions

Notable variants

The highest-ranked variants include rs1057519748, rs1057519751, rs1060499616, rs1060502579, and rs121912498, each carrying a cancer association at magnitude 5.50. A second cluster - rs1555884790, rs1555889984, rs1555899813, rs1569008655, and rs1569037127 - shares the same score and trait label. Further cancer-associated variants at the same magnitude include rs1569061762, rs1569061768, rs1569061831, rs1569078774, and rs1569079076. The uniform magnitude across all listed variants is notable; it may reflect a shared functional context, though no study-level data is available to confirm this.

Trait associations

Cancer is the sole trait represented in the characterized variant set for this gene. All 20 listed variants - from rs1057519748 through rs1569084451, including rs1569084082, rs1569084170, and rs1569084388 - carry this label at magnitude 5.50. The consistent recurrence of a single trait label across every characterized position strengthens the inference that this locus carries a cancer-related association; however, the specific cancer subtype is not specified in the available data.

Evidence quality

The dataset contains 931 catalogued variants for this gene, with all 20 top-ranked entries registering a cancer trait association at magnitude 5.50. No prior SNP-level research summaries are available, which means sample sizes, odds ratios, and replication status cannot be reported for any individual variant. This is a significant limitation: a magnitude score alone does not distinguish a large, replicated multi-cohort GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically linked to a trait) from a preliminary single-study result. The 27 variants flagged as having prior research summaries are noted in the file header but their summaries are not yet loaded, so the strongest findings for this gene remain uncharacterized here. Users seeking to interpret specific variants should consult primary literature directly.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual - the same variant can be present in many people who never develop cancer and absent in many who do. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.