ROBO2, variants, traits, and what the research shows

ROBO2 - what this gene does

ROBO2 (Roundabout Homolog 2) shows up most often in research linked to rare diseases and kidney-related conditions, based on the variants catalogued here. The variant data on file also connects to cardiovascular and cancer trait categories at lower magnitude.

Key takeaways

• Most of the highest-magnitude variants in this gene are linked to rare disease categories, with two also flagged for kidney-related traits.
• A smaller set of variants connects to cardiovascular and cancer trait categories.
• No effect sizes or replication details are yet available for the variants on file; treat all associations as preliminary signals.
• Having a variant in this gene does not predict any individual health outcome.
• This gene has 371 variants on file, with the 20 highest-magnitude ones described here.

Notable variants

The highest-magnitude entries all score 5.50. Fifteen of these are flagged for rare disease categories: rs139552984, rs200131009, rs200834587, rs201356083, rs372105678, rs372255515, rs372913645, rs373371736, rs746150931, rs747011633, rs747971442, rs761048204, rs762523752, rs766273161, and rs780171319. Two magnitude-5.50 variants, rs188582283 and rs759802937, carry kidney trait labels. At magnitude 4.50, rs12497518 is associated with cancer, rs13074390 with cardiovascular traits, and rs12497639 currently lacks a trait annotation.

Trait associations

Rare disease is the dominant trait theme, appearing across 15 of the 20 highlighted variants. Kidney-related traits appear across two high-magnitude variants, rs188582283 and rs759802937, suggesting a link that warrants further investigation. Single variants at lower magnitude point toward cardiovascular (rs13074390) and cancer (rs12497518) categories. No trait detail is on file for rs12497639.

Evidence quality

No detailed SNP summaries, including effect sizes, odds ratios, sample sizes, or replication status, are currently available for any variant in this gene. All associations listed here derive from variant metadata only and should be treated as preliminary signals. The concentration of high-magnitude rare-disease variants may reflect a clustering of low-frequency coding variants, which are often evaluated in smaller, disease-specific cohorts rather than large population GWAS (genome-wide association studies, meaning large scans that test millions of genetic variants across many thousands of people for statistical links with traits). Until effect sizes and replication data are available, no association here should be interpreted as confirmed.

What this is NOT

These variants represent population-level statistical associations, not deterministic predictors of any condition for any individual. This page does not prescribe, diagnose, or advise any course of action.