RNLS, variants, traits, and what the research shows

RNLS - what this gene does

RNLS is a human gene with variants linked across three broad trait themes in genomic research: rare disease, neurological conditions, and cancer. With 95 catalogued variants on file, this is a gene showing substantial genetic diversity across the human population.

Key takeaways

• The highest-magnitude variant in this gene is tied to a rare disease trait, the strongest single signal in the catalogue.
• Separate variants link this gene to neurological conditions and cancer, covering three distinct trait domains.
• 95 variants are catalogued in total, with 16 carrying prior published research context.
• These are population-level associations from genomic studies, not individual disease predictors.
• Effect size and replication details are limited in the available data, so findings should be interpreted cautiously.

Notable variants

rs143513862 carries the highest magnitude score on file - a combined measure of effect size and evidence strength - at 5.50, and is linked to a rare disease trait, making it the strongest single signal in this catalogue. At the next tier, rs10736354 has a published association with a neurological trait and rs117634027 is linked to cancer, both sitting at magnitude 4.50 with prior editorial coverage. Three additional magnitude-4.50 variants - rs2185786, rs2477954, and rs2576170 - appear at the same tier without specific trait annotations in the current data. A broader group of magnitude-3.00 variants, including rs1242739294, rs149300466, and rs147588689, rounds out the landscape without current trait labels.

Trait associations

The three primary trait categories where this gene appears in research are rare disease, neurological conditions, and cancer. The rare disease signal is anchored by rs143513862 at the highest magnitude tier on file. The neurological connection is represented by rs10736354, and the cancer connection by rs117634027. Several additional variants at magnitude 4.50 - rs2185786, rs2477954, and rs2576170 - sit in the same tier without current trait labels, suggesting that the full association picture for this gene may not yet be complete.

Evidence quality

The strongest signal in the dataset is rs143513862 at magnitude 5.50, linked to a rare disease trait. Two variants - rs10736354 and rs117634027 - have prior published editorial pages, indicating they have been reviewed in prior research contexts. However, specific effect sizes such as odds ratios (a ratio comparing how much more common a trait is in people with versus without a variant) or beta coefficients, sample sizes, and replication cohort details are not present in the current input for any variant. Without that detail, it is not possible to grade the robustness of individual findings beyond their relative magnitude tiers. The majority of the 95 catalogued variants sit at magnitude 3.00 without trait annotations and should be treated as preliminary signals pending further study.

What this is NOT

The variants catalogued here are population-level statistical signals from large-scale genomic studies, not deterministic predictors of disease or trait outcomes for any individual person. This content is informational only and does not constitute medical advice, a diagnosis, or a recommendation for any action.