RERE, variants, traits, and what the research shows

RERE - what this gene does

REREis a human gene with variants catalogued across two broad trait themes: rare disease and neurological conditions. No per-variant research summaries are currently available in this dataset, so the specific biological mechanisms cannot be characterized beyond these trait categories.

Key takeaways

• The gene has 507 catalogued variants, with the top 20 all scoring at magnitude 5.50 - the highest tier in the current dataset.
• These top-magnitude variants split between rare disease (11 variants) and neurological conditions (9 variants).
• No per-variant research summaries are on file yet, so specific condition names and effect sizes cannot be reported.
• All top-magnitude variants carry equal scores, pointing to a consistently strong signal across both trait themes.
• These are population-level statistical associations, not individual health predictions.

Notable variants

All 20 top-magnitude variants on file carry a magnitude score of 5.50. Within the rare disease category, notable rsids include rs1002074448, rs1158166019, rs1306272176, rs1342761401, and rs1350374523. Within the neurological category, notable rsids include rs1057518295, rs1178020687, rs1321809020, rs1553154132, and rs1557461427. Because no per-variant summaries are yet available, the specific traits or conditions tied to each rsid cannot be detailed here.

Trait associations

The 507 variants on file cluster around two trait themes. Among the 20 highest-magnitude variants, 11 are flagged under rare disease - including rs138193383, rs1421433644, rs149900041, rs1553155778, rs1641387459, and rs1641481122 alongside those named above - and 9 under neurological conditions, including rs1557582259, rs1557582271, rs1557583707, and rs1557586047. The presence of high-magnitude variants across two distinct trait themes is notable, but the absence of per-variant detail prevents any characterization of specific conditions or their relationships.

Evidence quality

The current dataset provides rsids and trait-category labels for 20 high-magnitude variants (all at magnitude 5.50) but does not include per-variant research summaries, effect sizes, odds ratios, or sample size information. Without those details it is not possible to assess whether findings derive from GWAS - genome-wide association studies, large scans of many people's genomes for variants statistically linked to a trait - or from clinical case series, nor whether results have been independently replicated across multiple cohorts. The magnitude score of 5.50 is consistent with a high-priority signal tier, but the absence of supporting metadata means the overall evidence quality cannot yet be fully evaluated.

What this is NOT

These variants are population-level statistical signals from group-level studies, not deterministic predictors of disease for any individual. This entry does not constitute medical advice, a diagnosis, or a recommendation of any action.