RCL1, variants, traits, and what the research shows

RCL1 - what this gene does

Variants catalogued at the RCL1 locus are associated with two trait themes in genetic research: rare diseases and blood coagulation - the biological process by which the body forms clots to stop bleeding. No detailed study summaries are yet available for the specific variants on file, so this entry characterizes the gene through the trait signals its variants carry.

Key takeaways

• The highest-magnitude variant at this locus is linked to a rare disease trait.
• Two variants are independently linked to blood coagulation traits.
• 106 variants are catalogued here; 21 carry prior research annotations.
• No effect sizes or replication data are yet available for any of these variants.
• These are population-level statistical signals - not individual health predictions.

Notable variants

The strongest signal on file is rs1816786087 (magnitude 5.50), which carries a rare disease association and stands notably above all other variants in the catalog. Two variants at the next evidence tier - rs13300663 and rs457287 - are both linked to coagulation traits at magnitude 4.50, providing a two-variant signal within the same biological domain. Also at magnitude 4.50, rs183710524 and rs76742217 appear in the catalog without specific trait labels at this time. A further fifteen variants - including rs1035115030, rs114500329, and rs115216700 - cluster at magnitude 3.00.

Trait associations

Two trait categories emerge from the variant data. The rare disease theme is anchored by rs1816786087, the highest-magnitude variant on file, which carries a rare disease tag. The coagulation theme is represented by rs13300663 and rs457287, both tagged with coagulation associations at the same magnitude level; their co-occurrence within a single trait category at the same evidence tier is a potentially meaningful signal, though formal replication data are not yet available.

Evidence quality

No detailed study summaries have been processed for any variant at this locus, so effect sizes (such as odds ratios - the relative change in odds of a trait per variant copy - or beta coefficients - the estimated per-copy change in a continuous measurement), sample sizes, and replication status cannot be reported here. Trait labels are categorical tags attached to the top variants: a rare disease label on rs1816786087 and coagulation labels on rs13300663 and rs457287. Magnitude scores reflect a combined estimate of effect size and evidence strength - they are not clinical risk scores. The 5.50 magnitude of rs1816786087 stands notably above the rest of the catalog, which clusters at 4.50 and 3.00. All findings should be treated as preliminary until full study metadata are available.

What this is NOT

These variants are population-level statistical associations - they describe patterns observed across large groups of people and are not deterministic predictors of any individual's health outcomes. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.