RABGAP1L, variants, traits, and what the research shows

RABGAP1L - what this gene does

Variants in RABGAP1L cluster around three broad trait themes in the available research: rare disease, neurological conditions, and mental health. The gene carries 205 catalogued variants, of which 28 have published research context.

Key takeaways

• RABGAP1L has 205 catalogued genetic variants, 28 with published research context.
• The top variant by effect-size estimate is linked to a rare disease trait.
• Two independent variants in this gene carry mental health associations.
• A separate variant is linked to a neurological trait.
• All associations are population-level statistical signals and do not predict individual health outcomes.

Notable variants

The single highest-magnitude variant on file is rs1035337401 (magnitude 5.0), linked to a rare disease trait - the largest effect-size estimate among all catalogued variants in this gene. At magnitude 4.5, a cluster of variants spans multiple trait domains: rs1653636 and rs2142633 each carry mental health associations, while rs1793291 is linked to a neurological trait. Several additional magnitude-4.5 variants - including rs10218528, rs115035596, rs116439969, and rs12076771 - have published research pages, though detailed editorial summaries are not currently available in the source data.

Trait associations

The variants in this gene touch three main trait areas. The rare disease signal is anchored by rs1035337401, the strongest variant by magnitude score. Mental health traits appear across at least two independent variants - rs1653636 and rs2142633 - which appearing within the same gene may suggest a shared biological pathway, though independent replication is needed to confirm this. A neurological trait association is noted for rs1793291. The remaining catalogued variants currently lack trait metadata in the source data.

Evidence quality

The dataset lists 205 variants in this gene, with 28 carrying prior research summaries. The strongest variant by magnitude, rs1035337401 (magnitude 5.0), is flagged for rare disease; magnitude scores reflect a combination of effect size and evidence strength, but specific odds ratios, sample sizes, and replication status are not available in the current source data for any of the variants listed here. The mental health associations (rs1653636 and rs2142633) and the neurological association (rs1793291) are each represented by a single variant without additional cohort information, and should be treated as preliminary signals pending independent replication.

What this is NOT

These variants represent population-level statistical associations - they are not deterministic predictors of disease or health outcomes for any individual. Nothing here constitutes medical advice, a diagnosis, or a clinical recommendation of any kind.