PLCL2, variants, traits, and what the research shows

PLCL2 - what this gene does

PLCL2 has variants catalogued across several trait categories, with the strongest published signals clustering around mental health and neurological research.

Key takeaways

• Five separate high-priority variants in this gene are linked to mental health traits
• One high-priority variant is associated with neurological traits
• Additional lower-priority variants connect to metabolic, musculoskeletal, liver, and rare disease research
• All signals are population-level associations from genetic studies, not individual-level predictors
• The gene has 99 catalogued variants, 16 of which have published research summaries

Notable variants

The top-ranked variants all reach a magnitude score of 4.50. Among these, five carry mental health trait tags: rs6773869, rs6783769, rs73139272, rs9857592, and rs9867227. At the same priority level, rs6779302 is tagged as a neurological variant. Two further magnitude-4.50 variants, rs111333873 and rs60884297, also appear at this top tier. Stepping down in priority, rs1372072 (magnitude 2.80) is linked to rare disease traits. At magnitude 2.20, rs10659825 carries a metabolic tag, rs11128810 carries a musculoskeletal tag, and rs116249776 carries a liver-related tag.

Trait associations

Mental health is the most prominently represented trait category, with five high-priority variants - rs6773869, rs6783769, rs73139272, rs9857592, and rs9867227 - all flagged at the highest priority tier. The convergence of five distinct variants on the same trait category adds weight to the signal compared to a single-variant finding. Neurological associations appear via rs6779302 at the same tier. Additional trait areas include rare disease (rs1372072), metabolic (rs10659825), musculoskeletal (rs11128810), and liver (rs116249776). A further eight magnitude-2.20 variants - rs114687225, rs114766804, rs1156336, rs115792481, rs115910097, rs115952894, rs116480867, and rs116529782 - have published pages in this system but do not carry specific trait tags in the current dataset.

Evidence quality

The strongest signals are the eight magnitude-4.50 variants, five of which share a mental health label - a degree of within-gene convergence worth noting even before specific study details are available. The evidence base consists of GWAS (genome-wide association studies - large scans of many people's DNA for variants statistically linked to a trait) findings. This gene has 99 total variants on file, 16 with published research summaries. However, the detailed editorial content for those summaries is not yet populated in the current dataset, so specific effect sizes (such as odds ratios or beta coefficients), sample sizes, and replication status across independent cohorts cannot be reported here. All associations should be treated as preliminary signals pending review of the full published literature for each variant.

What this is NOT

These variants are population-level statistical associations observed across large study cohorts, not deterministic predictors of any outcome for any individual. This content does not constitute medical advice, diagnosis, or any recommendation to take action.