PDE3B, variants, traits, and what the research shows

PDE3B - what this gene does

Based on the variants currently on file, this gene appears in genomic research across two trait themes: nutrition and rare disease.

Key takeaways

• Variants in this gene are linked to nutrition-related traits and rare disease conditions across a 192-variant dataset.
• The highest-magnitude variants score 5.50 - the top tier in this dataset - and appear in both nutrition and rare disease categories.
• No detailed study annotations are yet available; trait assignments reflect broad labels, not specific diagnoses.
• Population-level statistical signals like these cannot predict outcomes for any individual.
• Full variant annotations are pending; evidence summaries will be added as research is catalogued.

Notable variants

Among nutrition-linked entries, rs1422405747, rs1848879955, and rs781906434 carry the highest magnitude score of 5.50 in this dataset. On the rare disease side, eight variants reach that same top tier: rs1848324903, rs1848596931, rs199883994, rs199997444, rs2494267841, rs2494270607, rs781823033, and rs782006425. At magnitude 4.50, rs10832310 represents the nutrition-linked variant with the smallest effect score among the top-20 listed entries.

Trait associations

Nutrition-related traits account for 12 of the 20 highest-ranked variants: rs1422405747, rs1848879955, rs781906434, rs1306247629, rs1555014321, rs202011621, rs576642411, rs61495246, rs782242126, rs782285382, rs782459395, and rs10832310. Rare disease associations appear across the remaining eight variants - all at the highest magnitude tier, including rs1848324903, rs1848596931, rs199883994, rs199997444, rs2494267841, rs2494270607, rs781823033, and rs782006425. The concentration of rare disease variants at the highest magnitude tier is notable, though without underlying study metadata the significance of this clustering cannot be evaluated.

Evidence quality

No detailed research summaries are yet available for any of the 20 variants listed here; the data on file consists solely of rsid identifiers, magnitude scores, and broad trait-theme labels. Magnitude scores range from 4.50 (rs10832310) to 5.50 (multiple variants), but without underlying study metadata - such as sample sizes, odds ratios, GWAS (genome-wide association study - a scan of many people's genomes for variants statistically linked to a trait) cohort details, or replication status - the strength of each individual signal cannot be independently assessed. All entries should be treated as preliminary pointers pending full annotation.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual - the same variant can be present in people who never develop any associated trait. Nothing here constitutes medical advice, a diagnosis, or a recommendation of any kind.