PARD3B, variants, traits, and what the research shows

PARD3B - what this gene does

PARD3B is a gene whose catalogued variants span multiple trait categories including cancer, metabolic conditions, cardiovascular traits, respiratory phenotypes, coagulation, and liver-related traits.

Key takeaways

• Variants in this gene are associated with cancer, metabolic, cardiovascular, and respiratory trait categories in genomic research.
• Two separate variants are linked to metabolic traits, suggesting a potentially recurring signal in that domain.
• Coagulation and liver trait associations are also present in the catalogued data.
• One lower-magnitude variant is linked to rare disease phenotypes.
• All associations are population-level statistical signals, not deterministic predictors for any individual.

Notable variants

Among the highest-magnitude variants on file (all at magnitude 4.50), rs12988876 is associated with cancer traits. Two variants, rs1374714 and rs78980179, are both linked to metabolic traits, which may reflect a recurring association in that domain. Cardiovascular traits are represented by rs188937806, and respiratory traits by rs61741390. Coagulation associations appear in rs79648531, and liver-related traits in rs80119103. Three additional high-magnitude variants, rs115059941, rs11884476, and rs1207426, have published pages but detailed trait summaries were not available for this entry.

Trait associations

The variants catalogued for this gene touch on several distinct biological domains. Cancer associations appear in rs12988876. Metabolic traits are linked to both rs1374714 and rs78980179, and the presence of two independent metabolic-linked variants is notable, since replication across variants can strengthen the case for a genuine association. Cardiovascular traits appear in rs188937806, respiratory traits in rs61741390, coagulation traits in rs79648531, and liver-related traits in rs80119103. At a lower magnitude, rs1004483054 carries a rare disease trait association.

Evidence quality

173 variants are catalogued for this gene, with 18 carrying prior research summaries and the top-ranked entries scoring at magnitude 4.50, a combined measure of effect size and evidence strength used to prioritize variants. Most of these associations are expected to reflect GWAS (genome-wide association study, a research approach that scans the genomes of large numbers of people to find variants statistically linked to a trait) findings. Specific odds ratios, beta coefficients, and sample sizes are not included in the current dataset for these variants, which limits the ability to characterize any individual association precisely. Detailed editorial summaries were unavailable for the three variants with published pages (rs115059941, rs11884476, rs1207426), so those signals cannot be fully characterized here. The rare disease signal from rs1004483054 sits at a lower magnitude (3.00) and should be treated as preliminary.

What this is NOT

These variants are population-level statistical signals drawn from large genomic studies and are not deterministic predictors of health outcomes for any individual person. This content does not constitute medical advice, a clinical diagnosis, or a recommendation to take any action.