PAM, variants, traits, and what the research shows

PAM - what this gene does

Variants in PAM have been associated in genomic research with immune, cardiovascular, and neurological traits. Across 117 catalogued variants, the gene shows up in three distinct biological domains, though the published summaries available for individual variants are limited at this time.

Key takeaways

• Six PAM variants reach the highest evidence tier in this dataset, linked to immune, cardiovascular, and neurological traits
• Two independent top-tier variants both point to cardiovascular associations, which strengthens that signal within this gene
• 117 total variants are catalogued for this gene, with 18 carrying prior published research
• These are population-level genomic signals, not personal health predictions
• Most lower-magnitude variants in this gene currently lack published trait annotations

Notable variants

The six variants scoring highest on the magnitude scale (4.50, a combined measure of effect size and evidence strength) are rs10077788 (immune trait), rs114555443 (cardiovascular trait), rs26431 (neurological trait), rs7729395 (cardiovascular trait), rs405752, and rs72783837. The cardiovascular signal is particularly notable because two independent top-tier variants, rs114555443 and rs7729395, converge on the same broad domain. Fourteen additional variants cluster at magnitude 3.00, including rs113740014, rs138392424, rs1385984412, rs1420421974, and others, though most lack trait annotations in the current dataset.

Trait associations

The three trait themes visible in the top-tier variants are immune, cardiovascular, and neurological. The immune association is anchored by rs10077788 at the highest magnitude level. Two cardiovascular-linked variants, rs114555443 and rs7729395, both reach that same top tier, making cardiovascular the most multiply-supported trait theme among the named associations in this dataset. The neurological association rests on rs26431, also at the top magnitude tier. Trait annotations for the 14 magnitude-3.00 variants currently listed, including rs144216702, rs146925861, rs200453170, rs200635625, and rs201199380, are not available at this time.

Evidence quality

The six top-magnitude variants (each scoring 4.50) represent the strongest signals on file, and the fact that two cardiovascular variants independently reach that tier offers modest within-gene replication of that association. However, the editorial summaries for rs10077788 and rs114555443, the two variants with dedicated pages, contain no published detail at this time, so mechanistic or clinical context for those signals cannot be described here. The remaining variants carry no trait annotations in this dataset. These associations come from GWAS studies (genome-wide association studies, large population scans that identify genetic variants statistically linked to a trait), and most lack reported odds ratios or sample sizes in the current summary. All associations here should be treated as preliminary until individual variant pages are more fully populated.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. This page does not prescribe, diagnose, or recommend any course of action.