NFATC1, variants, traits, and what the research shows

NFATC1 - what this gene does

NFATC1 (Nuclear Factor of Activated T-Cells Cytoplasmic 1, also listed as NF-ATc1) is a human gene whose catalogued variants cluster around three trait themes: rare diseases, liver conditions, and cancer.

Key takeaways

• Six of the highest-magnitude variants in this gene are linked to rare disease categories
• A liver-associated variant and a cancer-associated variant rank among the stronger signals on file
• 183 variants are catalogued for this gene, with detailed research summaries available for only 16
• All signals are population-level statistical associations, not individual-level predictions
• Evidence strength ranges from a magnitude score of 5.50 at the top end to 3.00 for lower-tier entries

Notable variants

The six highest-magnitude entries, each scoring 5.50, are all tagged as rare-disease signals: rs199958849, rs376070934, rs376173313, rs753211496, rs754370015, and rs779877080. At the next tier (magnitude 4.50), rs11663201 carries a liver-related association and has a published research page on file. The cancer-linked signal rs73007688 (magnitude 4.50) and two additional magnitude-4.50 variants, rs28627209 and rs4799055, round out the upper range of catalogued evidence.

Trait associations

Three trait themes run through the variant data. The rare-disease signal is the most concentrated, appearing across all six of the top-magnitude entries - rs199958849, rs376070934, rs376173313, rs753211496, rs754370015, and rs779877080. Liver conditions surface through rs11663201, and cancer through rs73007688. Lower-magnitude entries including rs1032564535, rs1170407308, rs1200856303, and rs1205294889 add to the breadth of associations, though their specific trait categories are not fully documented in the current dataset.

Evidence quality

The six rare-disease-linked variants at magnitude 5.50 represent the strongest signals in this dataset, though their specific effect sizes and sample sizes are not detailed in the available summaries. The liver variant rs11663201 and the cancer variant rs73007688 sit at magnitude 4.50, and rs11663201 has a published research page available. Of the 183 total variants on file, only 16 carry prior research summaries, which limits the depth of interpretation possible here. Where replication status, cohort size, or effect-size data are absent from the source material, those details are not reported.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies - studies that scan many people's genomes for variants statistically associated with a trait), not deterministic predictors for any individual. This content is informational only; we do not prescribe, diagnose, or advise any course of action.