NECTIN2, variants, traits, and what the research shows

NECTIN2 - what this gene does

NECTIN2 is a human gene whose variants have been catalogued across multiple trait areas in genetic research. Based on the variant data on file, this gene shows statistical associations with neurological conditions, metabolic measures, kidney function, cardiovascular health, and rare disease signals.

Key takeaways

• Variants in NECTIN2 have been statistically linked to neurological, metabolic, kidney, and cardiovascular traits in genetic research.
• The strongest signals on file span all four of those trait categories at the highest available magnitude rating.
• Lower-magnitude variants have also been flagged in rare disease contexts.
• 159 variants are catalogued for this gene, with 17 carrying published research summaries.
• These are population-level statistical signals from genetic studies, not individual health predictions.

Notable variants

The highest-magnitude signals on file (magnitude 4.50) appear across four distinct trait areas. On the neurological side, rs11665676 and rs419010 both reach this tier. Metabolic traits are represented by rs138607350, rs183427010, rs41289512, and rs79701229. Kidney-related associations appear at rs41290100 and rs41290108. A cardiovascular signal appears at rs6859. Note that rs139989004 also sits at magnitude 4.50 but currently lacks a trait annotation in the catalogue.

Trait associations

Neurological traits appear across three catalogued variants: rs11665676 and rs419010 at the top magnitude tier (4.50), and rs1365743374 at magnitude 3.00. Metabolic associations are the most numerous among top-tier signals, with four variants at magnitude 4.50 (rs138607350, rs183427010, rs41289512, rs79701229) and one at magnitude 2.20 (rs10410835). Kidney signals appear at three variants: rs41290100 and rs41290108 at magnitude 4.50, and rs1871047 at magnitude 2.80. The cardiovascular association is carried by rs6859 at magnitude 4.50. Rare disease signals appear at two lower-magnitude variants, rs1276887019 and rs539311376, both at magnitude 3.00, a preliminary finding that warrants further investigation.

Evidence quality

This gene has 159 catalogued variants on file, of which 17 have prior research summaries, indicating a moderate depth of study for a gene with this breadth of trait associations. Three variants carry dedicated published research pages: rs11665676, rs10410835, and rs112283362. The top-magnitude tier (4.50) contains 10 variants spanning four distinct trait categories. Several variants at magnitudes 2.20 to 3.00 lack trait annotations entirely, limiting interpretation of their significance. Effect sizes, odds ratios, sample sizes, and replication status across individual cohorts are not available in the current input summary and should be sought in primary literature before drawing conclusions.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies - large scans of many people's genomes for variants statistically linked to a trait) and related genetic research; they are not deterministic predictors of any individual's health outcomes. This content does not constitute medical advice, a diagnosis, or a recommendation of any kind.