NAV3, variants, traits, and what the research shows

NAV3 - what this gene does

Variants in NAV3 have been identified across three trait domains in the current dataset: cancer, neurological conditions, and mental health.

Key takeaways

• Three separate NAV3 variants are statistically linked to cancer in genome-wide research
• One variant shows association with neurological traits, another with mental health conditions
• One variant is linked to immune function
• All associations are population-level statistical signals, not individual risk predictions
• The dataset contains 200 NAV3 variants, with detailed summaries available for 16

Notable variants

The strongest-magnitude variants in this gene (all at magnitude 4.50, the highest tier in this dataset) cover several trait categories. Three variants linked to cancer are rs148904951, rs1491041, and rs7975770. Neurological traits are associated with rs695916, while mental health conditions appear in the signal from rs73425402. Immune function is represented by rs7957582. Several additional magnitude-4.50 variants - including rs10506772, rs10777559, rs1402279, and rs1479010 - appear in the dataset without trait labels at this time.

Trait associations

Cancer is the most represented trait theme among the highest-magnitude variants, with three separate hits - rs148904951, rs1491041, and rs7975770 - at the same magnitude tier. This clustering may reflect a more consistent signal in that domain, though specific cancer subtypes, effect sizes, and replication counts are not available in the current summaries. Neurological associations are anchored by rs695916 and mental health by rs73425402. Immune function shows up via rs7957582.

Evidence quality

The highest-magnitude variants carry a score of 4.50, representing the top evidence tier in this dataset. However, specific effect sizes (such as odds ratios or beta coefficients), sample sizes, and replication counts are not included in the available summaries, which limits precise characterization of association strength. Of the 200 variants on file for this gene, 16 have prior research summaries; the one published summary (rs10506772) does not currently contain detail. Most associations here should be treated as GWAS (genome-wide association study - a scan of many people's DNA for variants statistically linked to a trait) discovery signals awaiting further characterization.

What this is NOT

These variants are population-level statistical signals from studies of large groups of people, not deterministic predictors of any outcome for any individual. This content does not constitute medical advice, a diagnosis, or a recommendation for any action.