MIR3681HG, variants, traits, and what the research shows

MIR3681HG - what this gene does

Variants catalogued within MIR3681HG span several distinct trait categories - most prominently nutrition, pharmacogenomics (how the body processes medications), and respiratory health - making this a genomic locus (a specific position in the genome) of interest across multiple areas of population research.

Key takeaways

• Variants in this gene appear in research on nutrition, drug metabolism, and respiratory health.
• Three independent pharmacogenomics signals make drug-response research the most replicated theme in the available data.
• Additional signals span kidney function, neurological outcomes, immune response, mental health, and rare disease.
• All described associations are population-level statistical findings, not predictions for any individual.
• 99 variants are catalogued for this gene, with 23 carrying published research summaries.

Notable variants

Among the highest-priority variants (magnitude 4.50 - a relative measure of effect size and evidence strength used in this catalog), rs118096157 is associated with a nutrition trait, rs2165220 links to respiratory health, and rs2581066 connects to kidney function. Two variants at this same tier - rs142987647 and rs972874 - are each independently flagged for pharmacogenomics associations, making them the only pair within this gene to share a trait theme at the highest magnitude tier. rs76972305 is the sole top-tier variant flagged for a neurological trait. At a lower magnitude tier (2.80), rs116307278 adds a third pharmacogenomics signal, rs10929808 is linked to mental health, and rs1881145 to immune function.

Trait associations

Pharmacogenomics is the most replicated theme across this gene's dataset, with three independent variants - rs142987647, rs972874, and rs116307278 - each flagged for drug-response associations. Nutrition signals appear across two variants: rs118096157 at the highest priority tier and rs181139860 at the lower tier. Single-variant signals also appear for respiratory health (rs2165220), kidney function (rs2581066), neurological outcomes (rs76972305), immune function (rs1881145), mental health (rs10929808), and rare disease (rs17551536). The breadth of trait coverage - nine distinct domains across 20 listed variants - is notable, though most domains are represented by a single variant.

Evidence quality

The strongest signals in this dataset carry a magnitude of 4.50. Three variants have dedicated published pages - rs116307278, rs10929808, and rs118096157 - however, the editorial summaries available here did not include extractable data on study design, sample sizes, cohort composition, or specific effect sizes. Seventy-six of the 99 on-file variants lack any published research summary, meaning the evidence base for this locus remains largely uncharacterized in this catalog. All associations should be treated as preliminary until cohort sizes, replication across independent studies, and peer-reviewed effect-size estimates are confirmed.

What this is NOT

The variants described here are population-level statistical associations derived from genome-wide research - not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take or avoid any action.