MICAL2, variants, traits, and what the research shows

MICAL2 - what this gene does

MICAL2 is a human gene whose catalogued variants span four broad trait categories: rare disease, neurological, cardiovascular, and metabolic. The trait themes visible across its variants suggest a wide research footprint, though detailed mechanistic information is not available in the current dataset.

Key takeaways

• The strongest variant signal in this gene is linked to a rare disease trait
• Separate variants independently connect this gene to both neurological and cardiovascular conditions, with at least two variants appearing in each of those categories
• A metabolic trait association also appears among the top-ranked variants
• Most of the 162 variants on file lack detailed trait labels, so the full scope of associations is not yet established
• All associations are population-level statistical signals, not individual outcome predictions

Notable variants

The highest-magnitude variant on file is rs77782413 (magnitude 5.50), linked to a rare disease trait and standing clearly above the rest. Among the magnitude 4.50 variants, rs114029559 and rs117250828 are both associated with neurological traits, while rs11604904 and rs1994318 are each linked to cardiovascular traits. rs192936921 carries a metabolic trait association. rs12282110 and rs2706660 also rank among the higher-magnitude variants, though detailed trait information is not available for either in the current dataset.

Trait associations

This gene's catalogued variants cover four trait categories. The rare disease category is anchored by rs77782413, which holds the highest magnitude score of any variant in this gene. Neurological trait associations appear in at least two independent variants, rs114029559 and rs117250828, which modestly strengthens that signal by providing more than one data point. Cardiovascular associations are similarly represented by two independent variants, rs11604904 and rs1994318, again suggesting the link is not confined to a single observation. A metabolic trait association is present in rs192936921.

Evidence quality

Of 162 variants on file, 16 have prior research summaries, and 6 of the 8 highest-ranked variants by magnitude carry named trait labels - a reasonable coverage at the top of the list. The two-variant replication of neurological signals (rs114029559 and rs117250828) and the two-variant replication of cardiovascular signals (rs11604904 and rs1994318) each represent a modest strength of evidence compared to single-variant observations. However, no effect sizes such as odds ratios or beta coefficients are available in the provided data, no sample sizes are reported, and the research summaries for rs12282110, rs11604904, and rs117250828 do not currently contain detailed content. The remaining 154 variants, including all 12 listed at magnitude 3.00, carry no trait labels in this dataset. All findings should be treated as preliminary until fuller evidence is available.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies - a method that scans large groups of people for genetic variants statistically linked to a trait), not deterministic predictors of any outcome for any individual. We do not prescribe, diagnose, or advise based on this information.