MGMT, variants, traits, and what the research shows

MGMT - what this gene does

Variants catalogued in MGMT span three trait themes seen in published genetic research: pharmacogenomics (the study of how genetic variation influences drug response), cancer, and mental health.

Key takeaways

• MGMT variants have been studied in relation to pharmacogenomics, cancer, and mental health.
• Two distinct cancer-associated variants independently reach the highest evidence tier in this gene, lending some weight to the cancer signal.
• A pharmacogenomics variant in this gene has a dedicated research page in this encyclopedia, signaling an established research profile.
• 95 variants are catalogued in this gene, but most do not yet carry detailed trait annotations in our database.
• All variant signals shown here are population-level statistical associations, not predictors for any individual.

Notable variants

The six highest-scored variants each carry a magnitude of 4.50 in our evidence-weighted ranking. rs1008982 is linked to pharmacogenomics and has a dedicated editorial page. rs535664911 and rs76420701 are both associated with cancer, representing two independent top-tier signals for that trait. rs7078706 is linked to mental health. rs527496150 and rs74778840 share the same top magnitude score but have not yet been assigned trait annotations in our database.

Trait associations

Pharmacogenomics appears as a trait theme via rs1008982. Cancer associations are supported by at least two distinct high-magnitude variants - rs535664911 and rs76420701 - both independently reaching the top evidence tier, which strengthens the case that this gene is relevant to cancer biology. Mental health appears as a trait through rs7078706. A further 14 variants at a lower magnitude score are listed in the current view, most without trait annotations, and an additional 75 variants catalogued in this gene are not detailed in the current input.

Evidence quality

The six magnitude-4.50 variants represent the strongest signals on file for this gene. However, detailed statistics such as odds ratios, confidence intervals, and replication cohort sizes are not available in our database for most of them at this time. Of the 95 total variants catalogued, 18 are described as having prior research context, but only rs1008982 has a published editorial page in this encyclopedia at present. The majority of catalogued variants lack trait annotations, which limits any broad characterization of this gene's role. Readers should treat these findings as preliminary research signals pending fuller documentation.

What this is NOT

These variants represent population-level statistical associations, not deterministic predictors for any individual. This entry does not constitute medical advice, a diagnosis, or a recommendation to take any action.