LRRC4C, variants, traits, and what the research shows

LRRC4C - what this gene does

LRRC4C (leucine rich repeat containing 4C) is a human gene whose variants have been flagged across a strikingly broad range of trait categories - including cancer, cardiovascular disease, kidney conditions, neurological traits, respiratory conditions, nutritional phenotypes, and rare diseases - through genome-wide association studies (GWAS - large-scale scans of many people's genomes to find positions statistically linked to a trait).

Key takeaways

• Variants in this gene span at least seven distinct trait categories, including cancer, heart disease, kidney conditions, and neurological traits.
• The highest-magnitude variants in this dataset all reach a score of 4.50, the top level seen in this gene.
• Multiple variants share this top magnitude, suggesting the locus appears across several independent GWAS datasets.
• These are population-level statistical signals, not personal health predictors for any individual.
• Many variants here still lack published trait annotations, so the full picture of this gene's associations is still emerging.

Notable variants

The highest-magnitude variants each score 4.50. rs11036373 is linked to cancer-related traits; rs118140307 to cardiovascular traits; and rs12418938 to kidney-related traits. On the neurological side, rs2939755 carries the same top magnitude. Additional top-magnitude variants are tied to respiratory conditions (rs184852128), nutrition-related phenotypes (rs183497996), and rare disease categories (rs189511601). Several further magnitude-4.50 variants - including rs1038582711, rs140588512, rs191959849, rs4130394, rs4756618, rs528191121, rs76404044, and rs772231817 - appear in the dataset without specific trait annotations at this time.

Trait associations

The variants in this gene touch a wide arc of research areas: cancer (rs11036373), cardiovascular disease (rs118140307), kidney conditions (rs12418938), neurological traits (rs2939755), respiratory conditions (rs184852128), nutrition-related phenotypes (rs183497996), and rare disease categories (rs189511601). The breadth of these associations - spanning unrelated organ systems - is characteristic of a locus tagged by multiple independent GWAS signals rather than a single unified biological pathway. No single trait currently dominates the evidence base.

Evidence quality

The dataset contains 109 variants in this gene, 26 of which have prior published summaries. The top-tier variants cluster at a magnitude of 4.50, with a secondary tier at 3.00. Because the SNP-level summaries for the four highest-profile variants - rs118140307, rs12418938, rs11036373, and rs1038582711 - do not currently include sample sizes or effect-size data such as odds ratios or beta coefficients, the strength of individual signals cannot be further characterized here. The diversity of trait themes across unrelated organ systems suggests some associations may derive from different non-overlapping cohorts rather than replicated findings within any single phenotype - an important caveat when interpreting the apparent breadth of this gene's associations.

What this is NOT

These variants represent population-level statistical signals identified in large genetic studies, not deterministic predictors of any outcome for any individual. Nothing here constitutes a diagnosis, prognosis, or recommendation of any kind.