LPAR1, variants, traits, and what the research shows

LPAR1 - what this gene does

Variants at this locus have been studied in connection with vision, cardiovascular, and neurological traits - three distinct domains that together define the research landscape currently on file for this gene.

Key takeaways

• The three highest-magnitude variants at this locus each score 4.50 and span vision, cardiovascular, and neurological traits respectively.
• Vision is the most recurring theme, appearing in two separate variants in this dataset.
• 77 variants are on file in total, with 22 carrying prior research summaries.
• No effect sizes or sample sizes are currently available, so signal strength cannot be ranked beyond magnitude scores.
• All associations are population-level patterns from genetic studies - not predictions for any individual.

Notable variants

The three top-magnitude variants - rs10980623 (vision), rs10980624 (cardiovascular), and rs72748148 (neurological) - each carry a magnitude score of 4.50, the highest recorded at this locus. Magnitude scores are an internal measure of a variant's combined evidence strength and effect size. Vision also surfaces at lower magnitude through rs1007000. Two additional variants with published records, rs1000115 and rs1024771, carry magnitude scores of 2.20, though their trait labels are not available in the current dataset.

Trait associations

Vision is the most recurrent theme, appearing in both rs10980623 at high magnitude and rs1007000 at lower magnitude - two independent entries pointing to the same domain, which modestly strengthens that signal within this dataset. Cardiovascular traits are linked to rs10980624, and neurological traits to rs72748148, each at the same top magnitude tier. Fourteen additional variants carry a magnitude score of 3.00 but have no trait labels on file; their domain contributions cannot be assessed here.

Evidence quality

The current dataset does not include effect sizes - such as odds ratios (the ratio of the odds of a trait occurring in one group compared to another) or beta coefficients (the estimated change in a measurable trait per additional copy of a variant) - nor sample sizes or replication counts for any variant at this locus. The three highest-scoring variants share identical magnitude scores of 4.50, so no further ranking among them is possible from the available data alone. The 14 unlabeled magnitude-3.00 variants represent a substantial portion of the on-file catalog whose trait relevance remains unknown. Until effect sizes and cohort details are published, these associations should be treated as preliminary leads rather than established findings.

What this is NOT

These variants are population-level statistical signals - they describe patterns observed across many people, not outcomes for any individual. This content does not prescribe, diagnose, or recommend any course of action.