LINC02934, variants, traits, and what the research shows

LINC02934 - what this gene does

LINC02934 (Long Intergenic Non-Coding RNA 02934 - a class of genes that produce RNA molecules but not proteins) is a gene whose nearby variants have been catalogued across genome-wide association studies (GWAS - scans that test millions of genomic positions for statistical links to a trait) spanning cancer, cardiovascular, respiratory, neurological, and mental-health trait categories.

Key takeaways

• Variants in this gene span at least five disease areas: cancer, cardiovascular, respiratory, neurological, and mental health.
• The highest-magnitude variants link to cancer (three variants), respiratory conditions (two), and neurological traits (two).
• Lower-magnitude variants point toward metabolic and liver-related associations.
• All signals are population-level GWAS associations - not individual risk predictors.
• Detailed research summaries for most variants in this gene are still pending publication.

Notable variants

The strongest signals on file carry a magnitude score of 4.50. Cancer associations appear across rs115567527, rs149678059, and rs17030806. Respiratory-linked variants include rs185857144 and rs7597074. Neurological associations are reported for rs2287282 and rs6743531. A cardiovascular signal is flagged at rs13008718 and a mental-health signal at rs77987715. Four additional magnitude-4.50 variants - rs2287283, rs6546175, rs74424443, and rs770408932 - carry high scores but do not yet have trait assignments on file.

Trait associations

Cancer is the most represented trait category, with three high-magnitude variants (rs115567527, rs149678059, rs17030806) all at magnitude 4.50. Respiratory traits appear in two variants at the same tier (rs185857144 and rs7597074), as do neurological traits (rs2287282 and rs6743531) - the convergence of multiple independent variants on the same trait category is a modest corroborating signal, though not confirmation. A cardiovascular association is recorded at rs13008718 and a mental-health association at rs77987715. At lower magnitude (2.20), metabolic traits are tagged by rs10210513 and rs1032110, and a liver-related signal appears at rs10198404.

Evidence quality

Of the 140 variants on file, 21 carry prior research summaries, but the detailed editorial content for most of those pages - including rs10177161, rs1032110, rs10167906, rs10177183, rs10496132, rs10210513, and rs10198404 - has not been surfaced here. Effect sizes (such as odds ratios or beta coefficients), sample sizes, and replication status are unavailable for any variant in this gene, which substantially limits confidence. The trait labels represent statistical associations from GWAS scans only, not mechanistic findings or clinically validated relationships; the entire evidence base for this gene should be treated as preliminary.

What this is NOT

These variants are population-level statistical signals and are not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation for any action.