LINC02694, variants, traits, and what the research shows

LINC02694 - what this gene does

LINC02694 is a long intergenic non-coding RNA (lincRNA - a class of RNA molecules that carry no protein-coding instructions) gene region. Based on the variants catalogued here, this locus has been connected to a broad set of trait themes in genetic research: cancer, pharmacogenomics (how the body processes medicines), neurological conditions, mental health, sleep, coagulation (blood clotting), and immune function.

Key takeaways

• Two of the highest-magnitude variants in this region are independently associated with cancer traits
• Multiple variants carry pharmacogenomic signals, suggesting possible links to medicine response or metabolism
• Neurological and mental health associations appear across several separate variants, adding breadth to the signal
• Lower-magnitude variants connect this region to sleep quality and blood clotting
• All associations are population-level statistical findings, not deterministic predictors for any individual

Notable variants

The ten highest-magnitude variants all score 4.50. Among them, rs35151883 and rs72731219 are linked to cancer traits, while rs374299358 and rs61501627 carry pharmacogenomic associations. rs59659806 is flagged for mental health, and rs6492861 alongside rs7496143 both point to neurological traits. rs11070172 also holds a magnitude-4.50 signal and has a dedicated published page. At magnitude 2.80, rs1874252 adds an immune trait association and rs2643217 a second mental health signal.

Trait associations

Cancer signals appear in at least two top-magnitude variants - rs35151883 and rs72731219 - suggesting the cancer link is not a singleton within this locus. Pharmacogenomic associations span three variants: rs374299358, rs61501627, and rs10712877. Neurological trait connections appear across rs6492861, rs7496143, and rs10852028, and mental health associations are present in both rs59659806 and rs2643217. Among lower-magnitude variants, sleep traits are linked to rs10220877 and rs10520096; coagulation traits to rs10681907 and rs11070161; and immune function to rs1874252.

Evidence quality

Of the 145 variants on file for this gene, 20 are highlighted here; ten carry the highest observed magnitude of 4.50, and eight - rs11070172, rs10220877, rs10520096, rs10520107, rs10681907, rs10712877, rs10852028, and rs11070161 - have published editorial pages indicating prior review. Without individual effect sizes (such as odds ratios or beta coefficients) and sample sizes in this summary, the absolute strength of each association cannot be fully evaluated here; those details are carried in the individual SNP pages. The breadth of trait categories spanning cancer, neurology, pharmacogenomics, and sleep warrants caution: diverse GWAS associations across unrelated traits can sometimes reflect shared linkage-disequilibrium (LD - the tendency of nearby DNA variants to be inherited together) rather than direct causal effects at this locus.

What this is NOT

These variants are population-level statistical signals from GWAS (genome-wide association studies - research designs that scan hundreds of thousands of positions across many people's genomes for trait-linked patterns) and are not deterministic predictors of any trait or condition for any individual. This page does not constitute medical advice, a diagnosis, or a recommendation of any action.