LINC02580, variants, traits, and what the research shows

LINC02580 - what this gene does

LINC02580 (Long Intergenic Non-Coding RNA 2580) is a non-coding RNA gene, meaning it does not produce a protein. Based on the variant data catalogued here, the research signals associated with this gene span cardiovascular health, pharmacogenomics (how the body processes or responds to medications), and mental health.

Key takeaways

• Several independent variants near this gene are linked to cardiovascular health traits
• One high-magnitude variant is associated with pharmacogenomics - individual differences in medication response
• A separate high-magnitude variant is linked to mental health traits
• Secondary associations include liver function and immune-related traits
• All findings come from GWAS research, reflecting population-level tendencies rather than individual predictions

Notable variants

The highest-magnitude entries on file (scored 4.50 on an internal effect-plus-evidence metric) include rs116772368, which carries a pharmacogenomics association, rs12991132, linked to cardiovascular traits, and rs148578101, associated with mental health. Also at this magnitude tier are rs1002796, rs12615153, rs3179891, rs35136921, rs62137541, rs7562946, and rs7578467, though specific trait annotations for these are not available in the current dataset.

Trait associations

Cardiovascular traits show the broadest footprint across variants in this gene. At high magnitude, rs12991132 flags a cardiovascular link; at moderate magnitude, the same theme recurs independently through rs10167379, rs10207292, rs11900192, and rs12464602 - the convergence of multiple independent variants on the same trait strengthens the overall signal. Pharmacogenomics is represented at high magnitude by rs116772368. Mental health enters through rs148578101. Liver-related traits appear via rs11690947, and immune function through rs12466022.

Evidence quality

Of 83 catalogued variants in this gene, 17 carry prior research summaries. The cardiovascular signal is the most replicated, appearing across at least five independent variants at two distinct magnitude tiers - a pattern more consistent with a genuine regional association than any single variant alone would suggest. The pharmacogenomics and mental health signals each rest on a single high-magnitude entry (rs116772368 and rs148578101 respectively), making both preliminary pending independent replication. All variant associations in this dataset derive from GWAS (genome-wide association studies, which scan hundreds of thousands of individuals' genomes for statistical correlations with measured traits) rather than from functional experiments or clinical data. GWAS findings reflect average tendencies across populations and do not establish biological mechanism.

What this is NOT

These variants are population-level statistical signals and are not deterministic predictors of any outcome for any individual. This content is informational only - we do not prescribe, diagnose, or advise on any course of action.