LINC01934, variants, traits, and what the research shows

LINC01934 - what this gene does

LINC01934 (a long intergenic non-coding RNA gene, meaning it encodes RNA molecules that are not translated into proteins) appears in population-level genomic research across cardiovascular, neurological, cancer, and immune trait themes. The biological function of this gene is not characterizable from the available variant data alone; what the evidence shows is a pattern of associations across these trait categories.

Key takeaways

• Variants near LINC01934 have been linked to cardiovascular, neurological, cancer, and immune traits in population-level genomic studies.
• The strongest-magnitude signals at this locus point to cardiovascular associations, supported by three separate high-magnitude variants.
• These are statistical associations from GWAS studies, not deterministic predictors for any individual.
• A subset of 16 variants at this locus have dedicated research summaries out of 83 total catalogued.
• As a long non-coding RNA gene, LINC01934's biological role is not fully characterized from the available variant data.

Notable variants

The highest-magnitude variants at this locus all carry a score of 4.50. Three are linked to cardiovascular traits: rs13413665, rs183003649, and rs7602460. rs35262123 carries the same magnitude and is associated with a neurological trait, while rs76771408 is linked to cancer. rs6731985 also registers at magnitude 4.50 but currently lacks a trait label in the available data. Among moderate-magnitude variants, rs1018326 (magnitude 2.80) is linked to immune function and has a published research summary.

Trait associations

Cardiovascular traits appear most prominently at this locus, represented by three separate magnitude-4.50 variants: rs13413665, rs183003649, and rs7602460. The convergence of three independent cardiovascular signals at the same locus strengthens that particular theme relative to traits represented by a single variant. A neurological association is supported by rs35262123, and a cancer-related signal appears via rs76771408. At lower magnitudes, variants at this locus are linked to immune traits (rs1018326, rs12615545), hormonal traits (rs1030964, rs11282358), respiratory traits (rs113142635), and neurological traits (rs10189949). Several additional variants including rs10930953, rs114961716, rs115145822, rs11678264, rs11684463, rs11690881, and rs11891215 have published research pages but lack trait labels in the current catalogue.

Evidence quality

The strongest signals at this locus (magnitude 4.50) cover cardiovascular, neurological, and cancer traits, but no effect sizes, sample sizes, or replication data are available in the current variant catalogue to further characterize these associations. The gene has 83 total variants on file, of which 16 have published research pages. These associations derive from GWAS (genome-wide association study, a method that scans many people's genomes for variants statistically linked to a trait) findings; without reported odds ratios, beta coefficients, or cohort details, the relative strength of each signal cannot be fully assessed. The appearance of three independent cardiovascular variants at the top magnitude tier is notable but requires replication and effect-size data before drawing stronger conclusions. All findings should be treated as preliminary.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors of any health outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.