KIF26B, variants, traits, and what the research shows

KIF26B - what this gene does

KIF26B has 189 catalogued variants spanning four trait themes: rare diseases, neurological conditions, immune function, and cancer. Detailed mechanistic data is not available in this dataset, so what follows is based entirely on the trait associations attached to the catalogued variants.

Key takeaways

• Variants in this gene have been linked to rare diseases, neurological conditions, immune traits, and cancer
• The highest-magnitude signals on file are rare-disease and neurological associations
• Four variants have been reviewed in prior published editorial work
• Most associations are population-level statistical findings from genome-wide studies, not guarantees for any individual
• Effect sizes and replication data are not available for most variants in this summary

Notable variants

The three highest-magnitude variants on file - rs200000695 (rare disease), rs749953234 (neurological), and rs886037758 (rare disease) - each carry a magnitude score of 5.50, the highest in this dataset. Several magnitude-4.50 variants reinforce the neurological theme, notably rs1093958, while immune signals appear through rs112844193 and rs575851173. A cancer association is noted for rs74226487. Additional rare-disease signals at magnitude 4.50 are carried by rs529486807 and rs548748856.

Trait associations

Across the catalogued variants, the clearest trait clusters are rare diseases (flagged by rs200000695, rs886037758, rs529486807, and rs548748856), neurological conditions (rs749953234 and rs1093958), and immune function (rs112844193 and rs575851173). A cancer signal appears through rs74226487. The recurrence of rare-disease and neurological associations across multiple independent variants is notable, though no effect sizes or mechanistic details are available to characterize these connections further.

Evidence quality

The strongest signals carry magnitude scores of 5.50 (one neurological, two rare disease) and the next tier sits at 4.50 across neurological, immune, rare-disease, and cancer traits. Four variants - rs1093958, rs1173644, rs1111815, and rs112844193 - have published editorial pages indicating prior review, but no trait detail or effect-size data was included in this input. Odds ratios, beta coefficients, sample sizes, and replication-cohort details are absent from the current dataset. The majority of associations are presumed GWAS (genome-wide association study, a method that scans large populations for genetic variants statistically linked to a trait) hits, which detect correlations rather than causal relationships and should be treated as preliminary unless independently replicated.

What this is NOT

These variants are population-level statistical signals, not deterministic predictors for any individual. Nothing here constitutes a diagnosis, prognosis, or recommendation of any kind.