KDM4C, variants, traits, and what the research shows

KDM4C - what this gene does

Based on the variant data available, KDM4C is a human gene whose catalogued variants are linked to methylation - the chemical tagging of DNA and proteins that influences how genes are switched on or off.

Key takeaways

• KDM4C variants are most consistently linked to methylation-related traits in the research data on file.
• Three variants reach the highest recorded magnitude for this gene: rs114111025, rs16925200, and rs183851388.
• 123 variants are catalogued in this gene, though specific trait labels are unavailable for the majority.
• Effect size and cohort replication data are not yet available for the top-ranked variants, so findings should be treated as preliminary.
• Population-level associations describe statistical trends across large groups - they are not deterministic predictors for any individual.

Notable variants

rs114111025, rs16925200, and rs183851388 each reach a magnitude score of 4.50 - the highest recorded for this gene in the current dataset. Of these three, rs114111025 carries an explicit methylation trait annotation. A further cluster of variants at magnitude 3.00 - including rs112782148, rs1225252760, rs1345992659, rs138388124, rs142354964, and rs147868042, among others - rounds out the on-file signals, though specific trait labels are not available for these entries in the current data.

Trait associations

Methylation is the sole trait theme annotated across this gene's variant catalogue. It is explicitly linked to rs114111025 at the highest observed magnitude (4.50). The remaining top-magnitude variants - rs16925200 and rs183851388 - share the same magnitude tier but do not carry trait labels in the current dataset. Across all 123 variants on file, the consistent appearance of methylation as the primary trait theme suggests that research into this gene has concentrated in the epigenomics space - the study of heritable changes in gene activity that do not alter the underlying DNA sequence.

Evidence quality

The published SNP summary for the top-ranked variant, rs114111025, does not yet contain detailed metadata - effect sizes (such as odds ratios or beta coefficients), sample sizes, or cohort replication information - in the current database. Without these metrics for any variant in this gene, the evidence base cannot be formally graded. The convergence of the top three signals at the same magnitude tier is consistent with a real association, but the absence of replication data and quantitative effect estimates means all findings here must be treated as preliminary.

What this is NOT

These variants are population-level statistical associations observed across large groups of people - they are not deterministic predictors of any trait or condition for any individual. Nothing here constitutes medical advice, a diagnosis, or a recommendation to take any action.