HLA-DRB5, variants, traits, and what the research shows

HLA-DRB5 - what this gene does

HLA-DRB5 (Human Leukocyte Antigen DRB5, a member of the HLA gene family) is catalogued with 71 variants in current research databases. The trait themes visible across this variant set span immune function, mental health, coagulation, liver-related phenotypes, and athletic performance.

Key takeaways

• Two variants at this locus carry the strongest signals on file, both linked to immune-related traits.
• Mental health is the most represented trait theme, with four separate variants appearing in that category.
• Coagulation, liver, and athletic performance traits also appear in the variant data.
• All signals here are population-level statistics from GWAS research, not personal health predictors.
• 71 variants are catalogued at this locus, with 19 carrying associated research content.

Notable variants

The two highest-magnitude entries are rs115711695 (magnitude 4.50, immune trait) and rs41553512 (magnitude 4.50), which stand clearly above the rest of the listed variants. One step below, rs193267147 (magnitude 2.80) is linked to mental health research. A cluster of variants at magnitude 2.20 rounds out the picture, including rs1064587 (coagulation), rs1136778 (liver), the pair rs113854881 and rs117108573 (athletic traits), and a mental health group consisting of rs112209031, rs113397282, and rs114875775.

Trait associations

Mental health is the most frequently represented theme across this gene's variants, with four entries - rs193267147, rs112209031, rs113397282, and rs114875775 - catalogued under that category. The appearance of the same trait theme across multiple independent variants at a single locus adds weight to the signal, though it does not confirm causation. Immune-related associations are anchored by the top-magnitude variant on file, rs115711695. Coagulation research flags rs1064587, liver-related research surfaces rs1136778, and athletic performance research captures the pair rs113854881 and rs117108573. Additional variants with published pages but no trait metadata on file include rs112587821, rs112668737, rs112749594, rs113496464, rs114604222, rs115001626, rs115488695, rs116370429, rs116708952, and rs117317282.

Evidence quality

The two top-magnitude variants, rs115711695 and rs41553512, both at 4.50, carry the strongest signals in this dataset and sit well above the 18 other listed variants, which cluster between 2.20 and 2.80. The full set of 71 catalogued variants reflects a locus with a broad footprint in GWAS (genome-wide association study - a study that scans many people's genomes for variants statistically associated with a trait) research. Because the prior SNP summaries for this entry do not include sample sizes, odds ratios, or replication cohort details, it is not possible to characterize individual study strength here. Treat all associations as hypothesis-generating signals unless a linked variant page provides further context.

What this is NOT

These variants are population-level statistical signals drawn from genome-wide association studies and are not deterministic predictors of any outcome for any individual. Nothing on this page constitutes medical advice, a diagnosis, or a recommendation to take any action.