HERC2, variants, traits, and what the research shows

HERC2 - what this gene does

No research summaries are available for individual variants in this entry, so this page characterizes HERC2 by the trait themes seen across its catalogued variants. The variants on file point to three broad domains: rare diseases, mental health conditions, and neurological conditions.

Key takeaways

• HERC2 variants have been flagged across rare disease, mental health, and neurological trait categories.
• Rare disease associations make up the largest share of the top-tier variants on file.
• Mental health associations appear in 6 of the 20 listed highest-magnitude variants.
• All 20 listed variants share the same magnitude score (5.50), reflecting a consistent evidence tier.
• These variants are population-level statistical signals, not deterministic predictors for any individual.

Notable variants

All 20 listed variants sit at magnitude 5.50, the top tier in the current dataset. The sole neurological entry is rs1057518934. Six variants are linked to mental health traits: rs112385654, rs146558015, rs1555415658, rs184647895, rs200457382, and rs200632307. The largest cluster, 13 variants, falls under the rare disease umbrella, including rs138338453, rs141969705, rs144218321, rs146303265, rs149437745, and rs200412833, among others.

Trait associations

Rare disease traits dominate the on-file record, with 13 of the 20 highest-magnitude variants tagged to this category: rs138338453, rs1385335623, rs140345440, rs141969705, rs142880342, rs1429361753, rs144218321, rs146303265, rs148225341, rs149437745, rs185865505, rs1891259083, and rs200412833. Mental health traits appear across 6 variants - rs112385654, rs146558015, rs1555415658, rs184647895, rs200457382, and rs200632307 - representing a secondary but notable theme. The neurological category is represented by a single high-magnitude entry, rs1057518934. Without detailed SNP summaries, the specific conditions within each broad category cannot be named here.

Evidence quality

Of 579 variants on file for this gene, 16 have prior research summaries, but none were available for this entry. The 20 variants described above all carry a magnitude of 5.50, the top tier in the current dataset. Because no study-level metadata - such as sample sizes, odds ratios, or replication cohort details - was provided in the input, it is not possible to characterize the depth of evidence behind individual variants. Readers should treat the trait-category tags as initial pointers, not confirmed associations, until full SNP summaries are reviewed.

What this is NOT

These variants represent population-level statistical associations observed in genomic research, not deterministic predictors of any individual's health outcomes. This entry does not prescribe, diagnose, or advise on any course of action.