GRID2, variants, traits, and what the research shows

GRID2 - what this gene does

Variants catalogued in GRID2 are most prominently linked to neurological conditions and rare diseases, with lower-magnitude signals also appearing in metabolic, cardiovascular, pharmacogenomic, and cancer trait categories.

Key takeaways

• The highest-magnitude variants in this gene are linked to neurological conditions and rare diseases
• Multiple independent variants share these trait themes across two magnitude tiers, which may indicate biological relevance
• Lower-magnitude variants connect this gene to metabolic, cardiovascular, pharmacogenomic, and cancer traits
• Most associations come from population-level studies and are not deterministic predictions for any individual
• Detailed effect sizes and replication data are not available for most variants in this catalog

Notable variants

Eight variants reach the highest magnitude on file (5.50). Three - rs144455304, rs1732687174, and rs750331613 - are linked to neurological traits; the remaining five (rs146342092, rs1726914026, rs202203896, rs538573274, rs762100538) are linked to rare diseases. The same pattern extends into the magnitude 5.00 tier, where rs1579319300, rs2546697844, and rs368143665 add further neurological signals and rs1470494014, rs2546697855, and rs2546697890 add rare-disease associations.

Trait associations

Neurological associations appear across at least six variants spanning two magnitude tiers: rs144455304, rs1732687174, and rs750331613 at magnitude 5.50, and rs1579319300, rs2546697844, and rs368143665 at magnitude 5.00. Rare-disease signals are similarly distributed across multiple variants at both magnitude levels. At magnitude 4.50, this gene also shows lower-strength associations with metabolic traits (rs10022753), cardiovascular traits (rs115632010), cancer (rs141643413), and pharmacogenomics - the study of how genetic variants influence individual drug response - (rs139857900, rs141321844).

Evidence quality

The highest-magnitude variants (5.50 and 5.00) cluster consistently around neurological and rare-disease trait categories, suggesting these represent the gene's primary area of research interest; however, specific effect sizes, sample sizes, and replication status are not available for individual variants in this dataset, which limits confidence in any single association. Two variants at magnitude 4.50 - rs10022753 for metabolic traits and rs115632010 for cardiovascular traits - have dedicated published pages that may indicate additional supporting evidence, though the content of those pages is not available here. All remaining signals should be treated as preliminary until independently replicated in large, well-powered cohorts.

What this is NOT

These variants represent population-level statistical signals - not deterministic predictors of disease or any individual outcome. This content is informational only; we do not prescribe, diagnose, or advise any action based on genetic data.