GMDS, variants, traits, and what the research shows

GMDS - what this gene does

GMDS is a human gene whose variants have been catalogued across several distinct health domains. Based on the research variants on file, this gene shows statistical associations with cancer, sleep-related traits, respiratory function, and metabolic phenotypes - identified through GWAS (genome-wide association studies, which scan large populations for genetic variants statistically linked to traits).

Key takeaways

• Variants in this gene have been linked to cancer risk, sleep-related traits, respiratory function, and metabolic phenotypes.
• The eight highest-magnitude variants on file span all four of those trait domains.
• 145 variants are catalogued in this gene, with 24 carrying prior research summaries.
• These are population-level associations from genome-wide studies, not individual predictions.
• Full effect sizes and study details are available on each variant's individual page.

Notable variants

The highest-magnitude variants (magnitude 4.50) span several trait domains. rs113685483 is linked to cancer, rs115625515 to sleep-related traits, rs2318089 to respiratory phenotypes, and rs77997740 to metabolic traits. Four additional variants at the same magnitude tier - rs112889634, rs6900744, rs7765461, and rs9378688 - carry published or curated records; their specific trait associations are detailed on their individual pages.

Trait associations

Four broad trait themes emerge from the catalogued variants. Cancer associations are represented by rs113685483. Sleep-related traits are flagged at rs115625515. Respiratory phenotypes appear at rs2318089. Metabolic traits are associated with rs77997740. A further tier of lower-magnitude variants (magnitude 3.00) - including rs1391141392, rs149819971, rs369492511, rs761030409, and others - adds to the catalogue, though specific trait labels are not available for all of these entries.

Evidence quality

Of 145 total variants catalogued in this gene, 24 carry prior research summaries, and three of the top-tier variants - rs112889634, rs113685483, and rs115625515 - have published editorial pages indicating reviewed evidence. The remaining high-magnitude variants are catalogued with trait labels or magnitude scores but without full summary statistics in this view. The lower-magnitude tier (magnitude 3.00, including rs749276776 and rs888240313 among twelve represented here) currently lacks specific trait metadata. Most associations originate from GWAS and represent statistical population-level signals; individual effect sizes and replication status should be verified on each variant's dedicated page before drawing any conclusions.

What this is NOT

These variants represent population-level statistical signals identified in research studies, not deterministic predictors of any outcome for any individual. This page does not prescribe, diagnose, or advise any course of action.